Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5852461..5853056 Replicon chromosome
Accession NZ_CP028584
Organism Pseudomonas aeruginosa strain WCHPA075019

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DBA97_RS27585 Protein ID WP_079752024.1
Coordinates 5852778..5853056 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DBA97_RS27580 Protein ID WP_083556829.1
Coordinates 5852461..5852766 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBA97_RS27565 5849185..5850048 - 864 WP_023098850.1 integrase domain-containing protein -
DBA97_RS27570 5850649..5851791 - 1143 WP_023098851.1 hypothetical protein -
DBA97_RS27580 5852461..5852766 - 306 WP_083556829.1 HigA family addiction module antidote protein Antitoxin
DBA97_RS27585 5852778..5853056 - 279 WP_079752024.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBA97_RS27590 5853109..5853335 - 227 Protein_5330 tyrosine-type recombinase/integrase -
DBA97_RS27595 5853704..5853907 + 204 WP_033971061.1 hypothetical protein -
DBA97_RS27605 5854329..5854844 - 516 WP_033971063.1 hypothetical protein -
DBA97_RS27610 5855151..5855801 - 651 WP_033971066.1 carbonate dehydratase -
DBA97_RS27615 5855863..5857101 - 1239 WP_088376614.1 C69 family dipeptidase -
DBA97_RS27620 5857300..5857752 - 453 WP_088376613.1 ribosomal protein S18-alanine N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5828905..5853907 25002


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10673.26 Da        Isoelectric Point: 8.5538

>T101531 WP_079752024.1 NZ_CP028584:c5853056-5852778 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAAKELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T101531 NZ_CP028584:c5853056-5852778 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAAGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11243.78 Da        Isoelectric Point: 4.7860

>AT101531 WP_083556829.1 NZ_CP028584:c5852766-5852461 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELKISPTALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT101531 NZ_CP028584:c5852766-5852461 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGAAGATCTCTCC
AACTGCTCTAGCACGCGCTTTGAACGTCTCCGCCCCGACAGTGAACGATATTGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGCCTGGGGCGTTACTTTGACACGTCCGCTCAGTTCTGGATGAATCTTCAGAGTGAGTATTCGTTGGCA
ACTGCTTATGCGGCGAACGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References