Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 527619..528239 | Replicon | |
| Accession | NC_016810 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | V1H8E6 |
| Locus tag | SL1344_RS02410 | Protein ID | WP_001280991.1 |
| Coordinates | 527619..527837 (-) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | V1H4V6 |
| Locus tag | SL1344_RS02415 | Protein ID | WP_000344807.1 |
| Coordinates | 527865..528239 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SL1344_RS02375 (SL1344_0459) | 522843..523412 | + | 570 | WP_000779803.1 | YbaY family lipoprotein | - |
| SL1344_RS02380 (SL1344_0460) | 523445..523834 | - | 390 | WP_000961284.1 | MGMT family protein | - |
| SL1344_RS02385 (SL1344_0461) | 524065..525615 | - | 1551 | WP_000213137.1 | EAL domain-containing protein | - |
| SL1344_RS02390 (SL1344_0462) | 525840..526100 | + | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
| SL1344_RS02395 (SL1344_0463) | 526106..526246 | + | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
| SL1344_RS02400 (SL1344_0464) | 526302..526772 | - | 471 | WP_000136181.1 | YlaC family protein | - |
| SL1344_RS02405 (SL1344_0465) | 526889..527440 | - | 552 | WP_001278792.1 | maltose O-acetyltransferase | - |
| SL1344_RS02410 (SL1344_0466) | 527619..527837 | - | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
| SL1344_RS02415 (SL1344_0467) | 527865..528239 | - | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
| SL1344_RS02420 (SL1344_0468) | 528735..531884 | - | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
| SL1344_RS02425 (SL1344_0469) | 531907..533100 | - | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T10152 WP_001280991.1 NC_016810:c527837-527619 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T10152 NC_016810:c527837-527619 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT10152 WP_000344807.1 NC_016810:c528239-527865 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT10152 NC_016810:c528239-527865 [Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10074 | Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S |
100 |
100 |
1 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10074 | Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S |
100 |
100 |
1 |
Multiple sequence alignment
References
(1) Sangeeta Jaiswal et al. (2016) The Hha-TomB Toxin-Antitoxin System Shows Conditional Toxicity and Promotes Persister Cell Formation by Inhibiting Apoptosis-Like Death in S. Typhimurium. Scientific Reports 6:38204. [PubMed:27910884]
(2) Prajita Paul et al. (2018) Molecular insight to influential role of Hha-TomB toxin-antitoxin system for antibacterial activity of biogenic silver nanoparticles. Artificial Cells, Nanomedicine, And Biotechnology 46(sup3):S572-S584. [PubMed:30444141]