Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 528825..529445 | Replicon | |
| Accession | NC_016856 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | V1H8E6 |
| Locus tag | STM14_RS02980 | Protein ID | WP_001280991.1 |
| Coordinates | 528825..529043 (-) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | V1H4V6 |
| Locus tag | STM14_RS02985 | Protein ID | WP_000344807.1 |
| Coordinates | 529071..529445 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| STM14_RS02945 (STM14_0549) | 524049..524618 | + | 570 | WP_000779803.1 | YbaY family lipoprotein | - |
| STM14_RS02950 (STM14_0550) | 524651..525040 | - | 390 | WP_000961285.1 | MGMT family protein | - |
| STM14_RS02955 (STM14_0552) | 525271..526821 | - | 1551 | WP_000213139.1 | EAL domain-containing protein | - |
| STM14_RS02960 (STM14_0553) | 527046..527306 | + | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
| STM14_RS02965 (STM14_0554) | 527312..527452 | + | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
| STM14_RS02970 (STM14_0555) | 527508..527978 | - | 471 | WP_000136181.1 | YlaC family protein | - |
| STM14_RS02975 (STM14_0556) | 528095..528646 | - | 552 | WP_001278792.1 | maltose O-acetyltransferase | - |
| STM14_RS02980 (STM14_0557) | 528825..529043 | - | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
| STM14_RS02985 (STM14_0558) | 529071..529445 | - | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
| STM14_RS02990 (STM14_0559) | 529941..533090 | - | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
| STM14_RS02995 (STM14_0560) | 533113..534306 | - | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T10074 WP_001280991.1 NC_016856:c529043-528825 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T10074 NC_016856:c529043-528825 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT10074 WP_000344807.1 NC_016856:c529445-529071 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT10074 NC_016856:c529445-529071 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10152 | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 |
100 |
100 |
1 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10152 | Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 |
100 |
100 |
1 |
Multiple sequence alignment
References
(1) Prajita Paul et al. (2022) The Hha-TomB toxin-antitoxin module in Salmonella enterica serovar Typhimurium limits its intracellular survival profile and regulates host immune response. Cell Biology And Toxicology 38(1):111-127. [PubMed:33651227]