Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 30479..31209 Replicon chromosome
Accession NZ_CP028538
Organism Enterobacter hormaechei strain SCEH020042

Toxin (Protein)


Gene name higB Uniprot ID A0A837FIL2
Locus tag DBP88_RS02330 Protein ID WP_023302825.1
Coordinates 30479..30793 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DBP88_RS02335 Protein ID WP_023305145.1
Coordinates 30790..31209 (+) Length 140 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBP88_RS02305 26145..27230 + 1086 Protein_25 cellulase family glycosylhydrolase -
DBP88_RS02310 27136..28320 - 1185 WP_023305143.1 multidrug efflux MFS transporter EmrD -
DBP88_RS02315 28496..29329 - 834 WP_023305144.1 DMT family transporter -
DBP88_RS02320 29392..29838 - 447 WP_023298965.1 GNAT family N-acetyltransferase -
DBP88_RS02325 29903..29992 - 90 WP_022646551.1 type I toxin-antitoxin system toxin TisB -
DBP88_RS02330 30479..30793 + 315 WP_023302825.1 type II toxin-antitoxin system HigB family toxin Toxin
DBP88_RS02335 30790..31209 + 420 WP_023305145.1 helix-turn-helix domain-containing protein Antitoxin
DBP88_RS02340 31356..31454 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
DBP88_RS02345 31561..33249 + 1689 WP_032676730.1 acetolactate synthase large subunit -
DBP88_RS02350 33253..33540 + 288 WP_010426528.1 acetolactate synthase small subunit -
DBP88_RS02355 33666..34259 + 594 WP_022646555.1 transcriptional regulator UhpA -
DBP88_RS02360 34256..35761 + 1506 WP_023305147.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 12415.51 Da        Isoelectric Point: 10.2825

>T101364 WP_023302825.1 NZ_CP028538:30479-30793 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

>T101364 NZ_CP028538:30479-30793 [Enterobacter hormaechei]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15508.15 Da        Isoelectric Point: 5.6761

>AT101364 WP_023305145.1 NZ_CP028538:30790-31209 [Enterobacter hormaechei]
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANRPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAVRFGVSPALFIE

Download         Length: 420 bp

>AT101364 NZ_CP028538:30790-31209 [Enterobacter hormaechei]
ATGATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGA
GAAAGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGCCCCTTGCTGGATATTGTTT
GCGCCAGAATTAGCCATTACGAAGCTAATCGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCTGTTCCCGTCGGA
ATTGCAGTTTTGAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGAT
GGTTTCACGGGTTCTGAATGGTCAGAGACAGCTTACTCTGAACCATATTAAAAAGCTGGCGGTCAGATTTGGGGTATCAC
CTGCGCTATTTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A837FIL2


Antitoxin

Source ID Structure

References