Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 847027..847673 Replicon chromosome
Accession NZ_CP028520
Organism Lelliottia sp. WB101

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DAI21_RS04010 Protein ID WP_107704215.1
Coordinates 847027..847377 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DAI21_RS04015 Protein ID WP_100778220.1
Coordinates 847374..847673 (+) Length 100 a.a.

Genomic Context

DAI21_RS03995DAI21_RS04005DAI21_RS04010DAI21_RS04015DAI21_RS04025DAI21_RS04030DAI21_RS04035DAI21_RS04040DAI21_RS04045DAI21_RS04000DAI21_RS04020
Location: 843498..846224 (2727 bp)
Type: Others
Protein ID: WP_159075404.1
Location: 846553..846843 (291 bp)
Type: Others
Protein ID: WP_107702546.1
Location: 847027..847377 (351 bp)
Type: Toxin
Protein ID: WP_107704215.1
Location: 847374..847673 (300 bp)
Type: Antitoxin
Protein ID: WP_100778220.1
Location: 849059..849496 (438 bp)
Type: Others
Protein ID: WP_107702548.1
Location: 849549..850277 (729 bp)
Type: Others
Protein ID: WP_100778223.1
Location: 850376..850786 (411 bp)
Type: Others
Protein ID: WP_107702549.1
Location: 850970..851404 (435 bp)
Type: Others
Protein ID: WP_100778225.1
Location: 851401..852120 (720 bp)
Type: Others
Protein ID: WP_107702550.1
Location: 846238..846429 (192 bp)
Type: Others
Protein ID: WP_107704214.1
Location: 847923..848921 (999 bp)
Type: Others
Protein ID: WP_107702547.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DAI21_RS03995843498..846224+2727WP_159075404.1SIR2 family protein-
DAI21_RS04000846238..846429-192WP_107704214.1toxin-antitoxin system HicB family antitoxin-
DAI21_RS04005846553..846843+291WP_107702546.1SymE family type I addiction module toxin-
DAI21_RS04010847027..847377+351WP_107704215.1type II toxin-antitoxin system RelE/ParE family toxinToxin
DAI21_RS04015847374..847673+300WP_100778220.1XRE family transcriptional regulatorAntitoxin
DAI21_RS04020847923..848921-999WP_107702547.1class I SAM-dependent methyltransferase-
DAI21_RS04025849059..849496+438WP_107702548.1hypothetical protein-
DAI21_RS04030849549..850277+729WP_100778223.1MerR family transcriptional regulator-
DAI21_RS04035850376..850786+411WP_107702549.1hydroxyisourate hydrolase-
DAI21_RS04040850970..851404+435WP_100778225.1nuclear transport factor 2 family protein-
DAI21_RS04045851401..852120+720WP_107702550.1SDR family NAD(P)-dependent oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13532.62 Da        Isoelectric Point: 8.9094

>T101351 WP_107704215.1 NZ_CP028520:847027-847377 [Lelliottia sp. WB101]
MWTVLVGKVFEQWLHEQEEGLQERVLAELLTLQNYGPHLTRPWADTVKGSRYNNMKELRIHYAGRPIRAFFAFDPVRQAI
VLCAGDKSNDKMFYKRLIRIADKEFSIHLAALETAN

Download         Length: 351 bp

>T101351 NZ_CP028520:847027-847377 [Lelliottia sp. WB101]
ATGTGGACGGTACTTGTAGGGAAGGTATTTGAACAATGGCTGCATGAGCAAGAAGAAGGGCTACAGGAAAGAGTATTAGC
AGAATTATTAACTCTGCAAAACTACGGACCGCATCTTACAAGACCCTGGGCCGATACCGTAAAAGGATCGCGGTATAACA
ATATGAAAGAGCTACGAATTCACTATGCTGGCCGTCCTATTCGTGCGTTCTTTGCTTTCGATCCCGTCCGCCAGGCGATC
GTGCTTTGTGCGGGTGACAAGAGTAACGACAAAATGTTTTATAAGCGGTTAATCCGTATTGCAGATAAAGAATTTTCGAT
TCATCTGGCAGCCCTGGAGACAGCAAATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11097.96 Da        Isoelectric Point: 7.0152

>AT101351 WP_100778220.1 NZ_CP028520:847374-847673 [Lelliottia sp. WB101]
MKTLNDVIASRSPESQQRIKEMADEMILETGLQMMREELKLSQQAVATIMGISQPAVTQLEQRGNELKIATLKRYIEAMG
GKLSLDVELPNGKRVAFHI

Download         Length: 300 bp

>AT101351 NZ_CP028520:847374-847673 [Lelliottia sp. WB101]
TTGAAAACCTTAAATGACGTGATTGCTTCCCGTTCGCCTGAAAGCCAGCAGCGTATCAAAGAGATGGCTGACGAGATGAT
TCTCGAAACCGGGCTACAGATGATGCGCGAAGAACTGAAACTATCTCAACAGGCGGTGGCGACAATAATGGGAATCAGCC
AACCCGCAGTTACCCAGCTTGAACAGCGCGGTAATGAACTGAAAATTGCTACGCTAAAACGCTACATCGAAGCGATGGGT
GGAAAACTGAGCCTGGATGTAGAACTGCCGAATGGGAAACGCGTGGCATTTCATATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References