Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 847027..847673 Replicon chromosome
Accession NZ_CP028520
Organism Lelliottia sp. WB101

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DAI21_RS04010 Protein ID WP_107704215.1
Coordinates 847027..847377 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DAI21_RS04015 Protein ID WP_100778220.1
Coordinates 847374..847673 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAI21_RS03995 843498..846224 + 2727 WP_159075404.1 SIR2 family protein -
DAI21_RS04000 846238..846429 - 192 WP_107704214.1 toxin-antitoxin system HicB family antitoxin -
DAI21_RS04005 846553..846843 + 291 WP_107702546.1 SymE family type I addiction module toxin -
DAI21_RS04010 847027..847377 + 351 WP_107704215.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAI21_RS04015 847374..847673 + 300 WP_100778220.1 XRE family transcriptional regulator Antitoxin
DAI21_RS04020 847923..848921 - 999 WP_107702547.1 class I SAM-dependent methyltransferase -
DAI21_RS04025 849059..849496 + 438 WP_107702548.1 hypothetical protein -
DAI21_RS04030 849549..850277 + 729 WP_100778223.1 MerR family transcriptional regulator -
DAI21_RS04035 850376..850786 + 411 WP_107702549.1 hydroxyisourate hydrolase -
DAI21_RS04040 850970..851404 + 435 WP_100778225.1 nuclear transport factor 2 family protein -
DAI21_RS04045 851401..852120 + 720 WP_107702550.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13532.62 Da        Isoelectric Point: 8.9094

>T101351 WP_107704215.1 NZ_CP028520:847027-847377 [Lelliottia sp. WB101]
MWTVLVGKVFEQWLHEQEEGLQERVLAELLTLQNYGPHLTRPWADTVKGSRYNNMKELRIHYAGRPIRAFFAFDPVRQAI
VLCAGDKSNDKMFYKRLIRIADKEFSIHLAALETAN

Download         Length: 351 bp

>T101351 NZ_CP028520:847027-847377 [Lelliottia sp. WB101]
ATGTGGACGGTACTTGTAGGGAAGGTATTTGAACAATGGCTGCATGAGCAAGAAGAAGGGCTACAGGAAAGAGTATTAGC
AGAATTATTAACTCTGCAAAACTACGGACCGCATCTTACAAGACCCTGGGCCGATACCGTAAAAGGATCGCGGTATAACA
ATATGAAAGAGCTACGAATTCACTATGCTGGCCGTCCTATTCGTGCGTTCTTTGCTTTCGATCCCGTCCGCCAGGCGATC
GTGCTTTGTGCGGGTGACAAGAGTAACGACAAAATGTTTTATAAGCGGTTAATCCGTATTGCAGATAAAGAATTTTCGAT
TCATCTGGCAGCCCTGGAGACAGCAAATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11097.96 Da        Isoelectric Point: 7.0152

>AT101351 WP_100778220.1 NZ_CP028520:847374-847673 [Lelliottia sp. WB101]
MKTLNDVIASRSPESQQRIKEMADEMILETGLQMMREELKLSQQAVATIMGISQPAVTQLEQRGNELKIATLKRYIEAMG
GKLSLDVELPNGKRVAFHI

Download         Length: 300 bp

>AT101351 NZ_CP028520:847374-847673 [Lelliottia sp. WB101]
TTGAAAACCTTAAATGACGTGATTGCTTCCCGTTCGCCTGAAAGCCAGCAGCGTATCAAAGAGATGGCTGACGAGATGAT
TCTCGAAACCGGGCTACAGATGATGCGCGAAGAACTGAAACTATCTCAACAGGCGGTGGCGACAATAATGGGAATCAGCC
AACCCGCAGTTACCCAGCTTGAACAGCGCGGTAATGAACTGAAAATTGCTACGCTAAAACGCTACATCGAAGCGATGGGT
GGAAAACTGAGCCTGGATGTAGAACTGCCGAATGGGAAACGCGTGGCATTTCATATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References