101328

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 1810505..1811835 Replicon chromosome
Accession NZ_CP028487
Organism Yersinia massiliensis strain GTA

Toxin (Protein)


Gene name HipT Uniprot ID A0A2R4NNK4
Locus tag DA391_RS08310 Protein ID WP_050286363.1
Coordinates 1810505..1811527 (-) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A0T9T098
Locus tag DA391_RS08315 Protein ID WP_050079781.1
Coordinates 1811524..1811835 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DA391_RS08295 1806716..1808140 + 1425 WP_167311297.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
DA391_RS08300 1808308..1809282 + 975 WP_050286361.1 chemotaxis protein -
DA391_RS08305 1809515..1810297 + 783 WP_050079783.1 SDR family oxidoreductase -
DA391_RS08310 1810505..1811527 - 1023 WP_050286363.1 HipA domain-containing protein Toxin
DA391_RS08315 1811524..1811835 - 312 WP_050079781.1 HipA N-terminal domain-containing protein Antitoxin
DA391_RS08320 1811820..1812164 - 345 WP_050079780.1 hypothetical protein -
DA391_RS08325 1812531..1813145 + 615 WP_050079779.1 TetR/AcrR family transcriptional regulator -
DA391_RS08330 1813220..1814329 + 1110 WP_050079778.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38276.09 Da        Isoelectric Point: 6.9755

>T101328 WP_050286363.1 NZ_CP028487:c1811527-1810505 [Yersinia massiliensis]
MNPEHCLINLSRLKGAELKTGYSTKGIRHLFGRLEVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLEGGELMVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFEIPPFGLIAFKRDDNRSDELAFVIKRYDRLGADIMRLHQEQLDGAMG
LGDKYGNIDNKKAISYEKAAKFLNKSVSSSLKSMRDVFLRIVYAYILGNNDFHLRNFGIIHPEKGSSYLAPVYDFISVVP
YPAAFGEYLALPLLEREENDAASAPGLDSAYGEYLGADFILLAQGIGINPVLAKKWLTDVIKSHQLIIDTYTESHMPEAQ
REAVLKYVARRITLLAVTEL

Download         Length: 1023 bp

>T101328 NZ_CP028487:c1811527-1810505 [Yersinia massiliensis]
ATGAATCCAGAACACTGCCTGATAAATCTAAGCCGGCTTAAAGGAGCAGAGTTAAAAACGGGTTATTCAACAAAAGGGAT
TAGACATCTGTTTGGTCGCTTGGAAGTGGCCCTCAGCCTGCCTTTCACGCGAAGTCAGTTTATTCAGGAACTTCCTGAAC
GTCAGAAAGGGATGAGTATTTCAGGCTATCAACCTAAGTTATCTCTTCGCCTGGAGGGAGGGGAACTGATGGTCGTCAGC
AATGATGGTACCTATATCCTGAAACCCTCACCAGAAGAGTACCCACATCTGGCGGAAAACGAGCATGCGACAATGTGCGT
CATGCAACGTCTGAAATTTGAAATCCCGCCATTTGGACTGATAGCTTTCAAGCGCGACGATAACCGATCGGATGAATTGG
CTTTTGTGATCAAGAGGTATGACCGGCTGGGTGCAGATATAATGAGATTGCATCAAGAACAGTTGGATGGCGCGATGGGC
CTCGGCGATAAATATGGCAATATCGATAACAAGAAAGCCATCAGCTACGAGAAAGCCGCCAAATTCCTGAACAAGAGCGT
GAGTAGCAGCTTAAAGAGCATGCGTGACGTCTTTTTACGAATCGTCTATGCGTACATACTAGGCAATAATGATTTTCATC
TACGTAATTTCGGGATCATACACCCCGAAAAAGGTTCATCGTATCTGGCTCCTGTTTATGACTTTATCAGTGTTGTACCC
TACCCGGCAGCTTTCGGAGAATATTTAGCTCTACCTCTCCTTGAGCGCGAGGAAAATGATGCAGCGAGCGCTCCGGGGCT
GGATTCAGCCTACGGGGAATACTTGGGCGCAGACTTTATCCTTCTCGCGCAGGGCATAGGTATTAATCCGGTTTTAGCCA
AAAAATGGCTTACTGACGTGATTAAGAGCCATCAGTTGATCATCGATACTTACACTGAAAGCCACATGCCAGAAGCGCAA
CGTGAAGCAGTGCTTAAGTACGTTGCACGGAGGATAACATTACTGGCAGTGACCGAACTTTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11748.64 Da        Isoelectric Point: 6.9762

>AT101328 WP_050079781.1 NZ_CP028487:c1811835-1811524 [Yersinia massiliensis]
MARKIGVWLYNKPVGTLSEEDIGFAFCYLANYTGRPISLSMPIRPEPYINQELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMQNGNDLLGAVVLKEITS

Download         Length: 312 bp

>AT101328 NZ_CP028487:c1811835-1811524 [Yersinia massiliensis]
ATGGCTCGAAAAATAGGTGTGTGGCTATACAACAAACCTGTAGGTACTTTGAGTGAAGAGGACATAGGTTTTGCCTTCTG
CTACCTAGCCAACTATACCGGCCGTCCTATATCGCTTAGCATGCCTATCAGGCCTGAACCTTATATTAATCAAGAACTTC
ATCCCTTCTTCAAAGGGTTGGCCCCAGAGGGTTGGCTGCGTAAACGATATTCTGAAATTCAAAAAATTGACGATAAGGAT
CTGTTCGGCTTACTGATGCAAAATGGTAACGACTTACTCGGGGCTGTAGTACTCAAAGAGATAACATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R4NNK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9T098

References