Detailed information of TA system TA101327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/MqsA(antitoxin)
• Location: 1431131..1431802
• Replicon: chromosome
• Accession: NZ_CP028487
• Organism: Yersinia massiliensis strain GTA

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0T9T807
• Locus tag: DA391_RS06575
• Protein ID: WP_050080100.1
• Coordinates: 1431131..1431463 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DA391_RS06580
• Protein ID: WP_050080099.1
• Coordinates: 1431482..1431802 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DA391_RS06555	1426733..1428391	+	1659	WP_050080104.1	indolepyruvate decarboxylase	-
DA391_RS06560	1428366..1429250	-	885	WP_050080103.1	LysR family transcriptional regulator	-
DA391_RS06565	1429352..1429834	+	483	WP_050080102.1	multidrug/biocide efflux PACE transporter	-
DA391_RS06570	1430003..1430974	+	972	WP_050287338.1	glucokinase	-
DA391_RS06575	1431131..1431463	+	333	WP_050080100.1	toxin	Toxin
DA391_RS06580	1431482..1431802	+	321	WP_050080099.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
DA391_RS06585	1431828..1433072	-	1245	WP_057649765.1	OFA family MFS transporter	-
DA391_RS06590	1433286..1434026	-	741	WP_050080097.1	LytTR family DNA-binding domain-containing protein	-
DA391_RS06595	1434030..1435730	-	1701	WP_050080096.1	sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin MqsA/HigA-2 (35-99)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12914.87 Da
• Isoelectric Point: 10.1237

>T101327 WP_050080100.1 NZ_CP028487:1431131-1431463 [Yersinia massiliensis]
MDAVFIELPPFERVRLDYLSDDDYRTLQTALMNNPTVGDVIQQTGGLRKMRFSEAKTGKGKRSGVRVIYYWWVERFQFLL
FTIYSKGEMSDLTHSQRKILSNLLKSRKSE

Nucleotide

• Length: 333 bp

>T101327 NZ_CP028487:1431131-1431463 [Yersinia massiliensis]
ATGGATGCTGTATTTATTGAATTGCCACCATTTGAACGCGTTAGATTAGATTACTTATCAGACGATGATTATCGAACCTT
GCAGACTGCATTAATGAATAACCCAACGGTTGGAGATGTTATTCAACAAACTGGCGGTTTGCGCAAAATGCGATTCAGTG
AGGCGAAAACAGGGAAGGGCAAGCGTAGTGGTGTCAGAGTCATTTATTATTGGTGGGTCGAGCGTTTTCAATTTTTGCTC
TTCACCATTTATAGCAAAGGTGAGATGTCTGACTTAACCCATTCGCAGCGGAAAATACTGAGTAATCTTCTTAAGTCCCG
TAAATCTGAATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12162.92 Da
• Isoelectric Point: 8.5292

>AT101327 WP_050080099.1 NZ_CP028487:1431482-1431802 [Yersinia massiliensis]
MKKRDLFSELVEGMEAWGEANTGKKTLKTHKVSTENTVTLTSEELRHIRETLNISQALFAHYLQAGIATYQNWEQGRAKP
NKQAILLIKMVQKDPHTLHTLAELYE

Nucleotide

• Length: 321 bp

>AT101327 NZ_CP028487:1431482-1431802 [Yersinia massiliensis]
ATGAAAAAAAGAGATTTATTTTCAGAATTGGTTGAGGGAATGGAAGCGTGGGGAGAGGCAAATACGGGAAAGAAGACACT
GAAAACCCACAAAGTCTCGACTGAGAATACCGTGACCCTGACGTCAGAAGAATTACGGCACATCCGTGAAACACTGAATA
TTTCGCAGGCGCTATTTGCGCATTACTTGCAGGCGGGTATTGCAACTTACCAGAATTGGGAGCAAGGCCGAGCCAAACCC
AATAAGCAGGCTATCTTACTGATTAAAATGGTACAAAAAGATCCCCATACACTGCATACGCTCGCTGAACTGTACGAATG
A

Structures

Toxin

• AlphaFold DB: A0A0T9T807