101257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2484895..2485418 Replicon chromosome
Accession NZ_CP028470
Organism Staphylococcus aureus strain IT4-R

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag C5Y81_RS12820 Protein ID WP_000074048.1
Coordinates 2484895..2485161 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag C5Y81_RS12825 Protein ID WP_000587616.1
Coordinates 2485161..2485418 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5Y81_RS12800 2480106..2481293 - 1188 WP_052997677.1 MFS transporter -
C5Y81_RS12805 2481687..2482463 - 777 WP_000072155.1 iron export ABC transporter permease subunit FetB -
C5Y81_RS12810 2482456..2483118 - 663 WP_000923509.1 ATP-binding cassette domain-containing protein -
C5Y81_RS12815 2483464..2484540 - 1077 WP_001076687.1 M42 family metallopeptidase -
C5Y81_RS12820 2484895..2485161 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
C5Y81_RS12825 2485161..2485418 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C5Y81_RS12835 2485777..2486232 + 456 WP_000732082.1 DUF1307 domain-containing protein -
C5Y81_RS12840 2486400..2487977 - 1578 WP_000143486.1 FMN-binding glutamate synthase family protein -
C5Y81_RS12845 2488172..2488921 + 750 WP_000072439.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T101257 WP_000074048.1 NZ_CP028470:c2485161-2484895 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T101257 NZ_CP028470:c2485161-2484895 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT101257 WP_000587616.1 NZ_CP028470:c2485418-2485161 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT101257 NZ_CP028470:c2485418-2485161 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References