Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2453601..2453785 Replicon chromosome
Accession NZ_CP028468
Organism Staphylococcus aureus strain IT1-S

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag C5Y45_RS12665 Protein ID WP_000482647.1
Coordinates 2453678..2453785 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2453601..2453661 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5Y45_RS12655 2449453..2451186 - 1734 WP_000486501.1 ABC transporter ATP-binding protein/permease -
C5Y45_RS12660 2451211..2452974 - 1764 Protein_2349 ABC transporter ATP-binding protein -
- 2453601..2453661 + 61 - - Antitoxin
C5Y45_RS12665 2453678..2453785 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
C5Y45_RS12670 2453919..2454305 - 387 WP_000779356.1 flippase GtxA -
C5Y45_RS12675 2454573..2455715 + 1143 WP_001176863.1 glycerate kinase -
C5Y45_RS12680 2455775..2456434 + 660 WP_000831298.1 membrane protein -
C5Y45_RS12685 2456613..2457824 + 1212 WP_001191976.1 multidrug effflux MFS transporter -
C5Y45_RS12690 2457947..2458420 - 474 WP_000456498.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgA / hlgC / hlgB 2437079..2454305 17226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T101239 WP_000482647.1 NZ_CP028468:c2453785-2453678 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T101239 NZ_CP028468:c2453785-2453678 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT101239 NZ_CP028468:2453601-2453661 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References