Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2427015..2427532 Replicon chromosome
Accession NZ_CP028468
Organism Staphylococcus aureus strain IT1-S

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag C5Y45_RS12510 Protein ID WP_000113261.1
Coordinates 2427015..2427281 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag C5Y45_RS12515 Protein ID WP_000584499.1
Coordinates 2427281..2427532 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5Y45_RS12485 2422452..2422988 - 537 WP_000169319.1 GNAT family N-acetyltransferase -
C5Y45_RS12490 2423222..2424046 - 825 WP_000594640.1 formate/nitrite transporter family protein -
C5Y45_RS12495 2424249..2424431 - 183 WP_000250735.1 hypothetical protein -
C5Y45_RS12500 2424518..2424985 - 468 WP_000153345.1 SRPBCC domain-containing protein -
C5Y45_RS12505 2425171..2426721 - 1551 WP_000727760.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
C5Y45_RS12510 2427015..2427281 - 267 WP_000113261.1 Txe/YoeB family addiction module toxin Toxin
C5Y45_RS12515 2427281..2427532 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C5Y45_RS12520 2427694..2427795 - 102 Protein_2324 hypothetical protein -
C5Y45_RS12525 2427802..2428401 - 600 WP_000162810.1 DsbA family protein -
C5Y45_RS12530 2428420..2428782 - 363 WP_000819843.1 DUF4467 domain-containing protein -
C5Y45_RS12535 2429037..2430287 + 1251 WP_001012231.1 FemA/FemB family glycyltransferase FmhA -
C5Y45_RS12540 2430372..2431103 - 732 WP_000615455.1 amino acid ABC transporter ATP-binding protein -
C5Y45_RS12545 2431100..2431819 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10452.02 Da        Isoelectric Point: 10.0373

>T101238 WP_000113261.1 NZ_CP028468:c2427281-2427015 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDKHIK
IASCKYHY

Download         Length: 267 bp

>T101238 NZ_CP028468:c2427281-2427015 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAAGCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT101238 WP_000584499.1 NZ_CP028468:c2427532-2427281 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT101238 NZ_CP028468:c2427532-2427281 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAGCACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References