Detailed information of TA system TA101230

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1961372..1961679
• Replicon: chromosome
• Accession: NZ_CP028468
• Organism: Staphylococcus aureus strain IT1-S

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: C5Y45_RS09915
• Protein ID: WP_072357969.1
• Coordinates: 1961503..1961679 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1961372..1961511 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5Y45_RS09865	1957165..1957377	-	213	Protein_1824	complement inhibitor SCIN-A	-
C5Y45_RS09870	1958060..1958509	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
C5Y45_RS09875	1958602..1958936	-	335	Protein_1826	SH3 domain-containing protein	-
C5Y45_RS09895	1959588..1960079	-	492	WP_000920041.1	staphylokinase	-
C5Y45_RS09900	1960270..1961025	-	756	WP_000861038.1	CHAP domain-containing protein	-
C5Y45_RS09905	1961037..1961291	-	255	WP_000611512.1	phage holin	-
C5Y45_RS09910	1961343..1961450	+	108	WP_031762631.1	hypothetical protein	-
-	1961372..1961511	+	140	NuclAT_0	-	Antitoxin
-	1961372..1961511	+	140	NuclAT_0	-	Antitoxin
-	1961372..1961511	+	140	NuclAT_0	-	Antitoxin
-	1961372..1961511	+	140	NuclAT_0	-	Antitoxin
C5Y45_RS09915	1961503..1961679	-	177	WP_072357969.1	putative holin-like toxin	Toxin
C5Y45_RS09920	1961831..1962127	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
C5Y45_RS09925	1962185..1962472	-	288	WP_001040261.1	hypothetical protein	-
C5Y45_RS09930	1962519..1962671	-	153	WP_001153681.1	hypothetical protein	-
C5Y45_RS09935	1962661..1966446	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / scn / chp / sak / hlb / tsst-1 / groEL	1954824..2031077	76253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T101230 WP_072357969.1 NZ_CP028468:c1961679-1961503 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T101230 NZ_CP028468:c1961679-1961503 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT101230 NZ_CP028468:1961372-1961511 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin