Detailed information of TA system TA101227

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1813700..1813880
• Replicon: chromosome
• Accession: NZ_CP028468
• Organism: Staphylococcus aureus strain IT1-S

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: C5Y45_RS08910
• Protein ID: WP_001801861.1
• Coordinates: 1813700..1813795 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1813823..1813880 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5Y45_RS08865	1809481..1810107	+	627	WP_000669029.1	hypothetical protein	-
C5Y45_RS08870	1810148..1810489	+	342	WP_000627536.1	DUF3969 family protein	-
C5Y45_RS08875	1810590..1811162	+	573	WP_000414208.1	hypothetical protein	-
C5Y45_RS08880	1811359..1811928	-	570	WP_000864144.1	ImmA/IrrE family metallo-endopeptidase	-
C5Y45_RS08890	1812301..1812477	-	177	WP_000375476.1	hypothetical protein	-
C5Y45_RS08895	1812488..1812871	-	384	WP_000070809.1	hypothetical protein	-
C5Y45_RS08900	1813053..1813277	-	225	WP_001805677.1	IS3 family transposase	-
C5Y45_RS08905	1813451..1813555	-	105	WP_001670380.1	transposase	-
C5Y45_RS08910	1813700..1813795	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1813823..1813880	-	58	-	-	Antitoxin
C5Y45_RS08915	1813918..1814019	+	102	WP_001791232.1	hypothetical protein	-
C5Y45_RS08920	1813997..1814169	-	173	Protein_1683	transposase	-
C5Y45_RS08925	1814363..1814740	-	378	WP_001036002.1	DUF1433 domain-containing protein	-
C5Y45_RS08930	1814946..1815386	-	441	WP_000759947.1	DUF1433 domain-containing protein	-
C5Y45_RS08935	1815431..1817044	+	1614	WP_000926708.1	lipase	-
C5Y45_RS08940	1817059..1817358	+	300	WP_000095392.1	WXG100 family type VII secretion target	-
C5Y45_RS08945	1817673..1818854	-	1182	WP_000162901.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk	1786551..1830108	43557

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T101227 WP_001801861.1 NZ_CP028468:1813700-1813795 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T101227 NZ_CP028468:1813700-1813795 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT101227 NZ_CP028468:c1813880-1813823 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin