Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1508575..1509087 Replicon chromosome
Accession NZ_CP028415
Organism Streptococcus mitis strain SK637

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag SK637_RS07575 Protein ID WP_000924721.1
Coordinates 1508575..1508829 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag SK637_RS07580 Protein ID WP_000388572.1
Coordinates 1508833..1509087 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SK637_RS07555 1504672..1504986 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
SK637_RS07560 1505011..1505637 - 627 WP_000775041.1 guanylate kinase -
SK637_RS07565 1505863..1506689 + 827 Protein_1386 DUF4839 domain-containing protein -
SK637_RS07570 1506760..1508373 - 1614 WP_000404934.1 ribonuclease Y -
SK637_RS07575 1508575..1508829 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
SK637_RS07580 1508833..1509087 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SK637_RS07585 1509219..1510316 - 1098 WP_033689226.1 nucleotidyltransferase -
SK637_RS07590 1510326..1511066 - 741 WP_033689653.1 class I SAM-dependent methyltransferase -
SK637_RS07595 1511175..1511528 - 354 WP_033689228.1 ribosome silencing factor -
SK637_RS07600 1511540..1512040 - 501 WP_033689230.1 cysteine hydrolase -
SK637_RS07605 1512041..1512634 - 594 WP_000331228.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
SK637_RS07610 1512634..1513263 - 630 WP_000963718.1 nicotinate-nucleotide adenylyltransferase -
SK637_RS07615 1513315..1513626 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T101148 WP_000924721.1 NZ_CP028415:c1508829-1508575 [Streptococcus mitis]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T101148 NZ_CP028415:c1508829-1508575 [Streptococcus mitis]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAGTATGACTACCAAG
GAGCTTGGTCACGTCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCTTTC
AAAGATCATTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT101148 WP_000388572.1 NZ_CP028415:c1509087-1508833 [Streptococcus mitis]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT101148 NZ_CP028415:c1509087-1508833 [Streptococcus mitis]
ATGGAAGCAGTTCTTTACTCAACGTTCCGAAATCATTTAAAAGACTACATGAAGAAGGTAAACGATGAATTTGAGCCTTT
GACGGTGGTTAATAAAAATCCAGACGAGGACATTGTAGTCCTTTCAAAGAGCGAGTGGGATAGTATTCAAGAAACTCTGA
GAATCGCTCAAAATAAGGAACTATCTGACAAGGTCTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGCACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References