Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1480123..1480778 Replicon chromosome
Accession NZ_CP028384
Organism Providencia heimbachae strain 99101

Toxin (Protein)


Gene name higB Uniprot ID A0A4D7IZ57
Locus tag C9446_RS06480 Protein ID WP_068909942.1
Coordinates 1480123..1480479 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1B7JJ80
Locus tag C9446_RS06485 Protein ID WP_068909944.1
Coordinates 1480479..1480778 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9446_RS06465 1475698..1476738 + 1041 WP_068909938.1 galactose-1-epimerase -
C9446_RS06470 1476935..1477933 + 999 WP_068445556.1 substrate-binding domain-containing protein -
C9446_RS06475 1478179..1479810 + 1632 WP_068445553.1 sodium/sugar symporter -
C9446_RS06480 1480123..1480479 + 357 WP_068909942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9446_RS06485 1480479..1480778 + 300 WP_068909944.1 helix-turn-helix domain-containing protein Antitoxin
C9446_RS06490 1480861..1482315 - 1455 WP_137021440.1 bifunctional 2-methylcitrate dehydratase/aconitate hydratase -
C9446_RS06495 1482329..1483492 - 1164 WP_137021441.1 2-methylcitrate synthase -
C9446_RS06500 1483548..1484438 - 891 WP_137021442.1 methylisocitrate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13976.32 Da        Isoelectric Point: 9.5588

>T101111 WP_068909942.1 NZ_CP028384:1480123-1480479 [Providencia heimbachae]
MTWKITTRPLFEAWFEEQNEAVQEETLSVLNILREYGPYIGRPQVDTLKDSKYRNMKELRIQVGGHPIRICFVFDPMRKG
VILCAGNKKGHDEKRFYSKLIRLADMEYSIYLKGIYKI

Download         Length: 357 bp

>T101111 NZ_CP028384:1480123-1480479 [Providencia heimbachae]
TTGACATGGAAGATAACAACAAGGCCACTTTTTGAAGCTTGGTTTGAAGAACAAAACGAAGCCGTACAAGAGGAGACACT
ATCCGTCTTGAATATTTTACGGGAGTACGGCCCTTATATTGGTCGTCCGCAAGTAGATACATTAAAGGACTCTAAGTATA
GAAATATGAAGGAGTTAAGAATTCAGGTGGGTGGTCATCCGATACGAATTTGCTTTGTATTTGACCCTATGAGGAAGGGC
GTAATATTGTGTGCGGGTAATAAAAAAGGTCATGATGAAAAACGATTTTATAGCAAACTAATTAGACTTGCAGATATGGA
ATATTCGATTTATTTAAAGGGGATATATAAAATATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11138.08 Da        Isoelectric Point: 10.0092

>AT101111 WP_068909944.1 NZ_CP028384:1480479-1480778 [Providencia heimbachae]
MGTLEELLAKRSPESLKRIEARVEELRREITLSKMREELNISQVQLAESLGIKQPAVVKMEKLGNDPKLSTIKRYVKALG
GELSLDVTLSNGKKLELHL

Download         Length: 300 bp

>AT101111 NZ_CP028384:1480479-1480778 [Providencia heimbachae]
ATGGGAACTTTAGAGGAACTACTGGCTAAACGCTCGCCTGAGAGCTTAAAGCGCATTGAAGCGCGAGTGGAAGAACTCCG
TCGTGAGATAACGTTATCTAAAATGCGAGAAGAGTTAAATATCTCACAAGTACAATTGGCTGAATCACTTGGGATTAAGC
AGCCCGCAGTGGTTAAGATGGAAAAATTGGGGAATGATCCCAAACTGTCGACGATTAAGCGTTACGTAAAGGCATTAGGG
GGCGAATTATCACTTGATGTCACTCTATCAAATGGTAAAAAACTTGAGCTTCATCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7IZ57

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JJ80

References