Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 943864..944399 Replicon chromosome
Accession NZ_CP028369
Organism Streptomyces sp. P3

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag C6376_RS04005 Protein ID WP_107442127.1
Coordinates 943864..944118 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C6376_RS04010 Protein ID WP_107442128.1
Coordinates 944115..944399 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C6376_RS03990 939330..941150 - 1821 WP_107442125.1 DUF4012 domain-containing protein -
C6376_RS43695 941503..941787 + 285 WP_159083155.1 hypothetical protein -
C6376_RS03995 941784..942884 + 1101 WP_107442126.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
C6376_RS04000 943154..943624 - 471 Protein_775 transposase -
C6376_RS04005 943864..944118 - 255 WP_107442127.1 Txe/YoeB family addiction module toxin Toxin
C6376_RS04010 944115..944399 - 285 WP_107442128.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
C6376_RS04015 944778..945053 + 276 WP_093723595.1 hypothetical protein -
C6376_RS04020 945050..945457 + 408 WP_107442129.1 PIN domain-containing protein -
C6376_RS04025 945916..946242 - 327 WP_107442130.1 thioredoxin -
C6376_RS44365 946485..946574 - 90 Protein_781 FAD-dependent oxidoreductase -
C6376_RS04040 946677..947456 - 780 WP_107442131.1 SDR family oxidoreductase -
C6376_RS04045 947559..947840 - 282 WP_107442132.1 hypothetical protein -
C6376_RS04050 947968..948927 - 960 WP_107442133.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10086.56 Da        Isoelectric Point: 8.4390

>T101044 WP_107442127.1 NZ_CP028369:c944118-943864 [Streptomyces sp. P3]
VRLVFEDQGWEDYTSWLKNDRKMLARINKLIEDVKRDPFTGIGKPEPLKYHLPGAWSRRTDDEHRLVYLVTDKEIVILAA
RYHY

Download         Length: 255 bp

>T101044 NZ_CP028369:c944118-943864 [Streptomyces sp. P3]
GTGAGGCTTGTCTTCGAGGACCAGGGCTGGGAGGACTACACGTCCTGGCTCAAGAACGACCGCAAGATGCTTGCTCGGAT
CAACAAGCTCATCGAGGACGTCAAGCGGGACCCCTTCACGGGGATCGGCAAGCCCGAGCCGCTGAAGTATCACTTGCCCG
GGGCCTGGTCGCGGCGGACCGACGATGAGCACCGCCTCGTCTACCTGGTGACGGACAAGGAGATCGTCATCCTCGCGGCT
CGTTACCACTACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10226.52 Da        Isoelectric Point: 5.6343

>AT101044 WP_107442128.1 NZ_CP028369:c944399-944115 [Streptomyces sp. P3]
MSITASEARKALFPLIKKVNDNHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALAHIDVSEREL
IDPDSPDAAREGAA

Download         Length: 285 bp

>AT101044 NZ_CP028369:c944399-944115 [Streptomyces sp. P3]
ATGTCCATAACTGCGAGCGAAGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGACAACCACGAGGCCATCGA
GATCGTCTCCAAGCACGGAAATGCCGTGCTCGTCTCGGCCGAGGACTATGCAGCGCTGCGCGAAGGCTCGTACCTCCTGC
GCTCTCCGGCGAACGCTCGCCGACTGCTCAAGGCGTACGAGAACGCCCTGGCCCACATCGACGTGTCCGAGCGAGAGCTG
ATCGACCCCGACTCGCCGGATGCGGCACGTGAGGGTGCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References