Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4075205..4075792 Replicon chromosome
Accession NZ_CP028358
Organism Stenotrophomonas maltophilia strain W18

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag C9J74_RS18990 Protein ID WP_080354792.1
Coordinates 4075514..4075792 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C9J74_RS18985 Protein ID WP_049443949.1
Coordinates 4075205..4075504 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J74_RS18965 4070641..4071828 + 1188 WP_088479129.1 pyridoxal phosphate-dependent aminotransferase -
C9J74_RS18970 4071941..4074037 - 2097 WP_057501083.1 prolyl oligopeptidase family protein -
C9J74_RS18975 4074107..4074433 - 327 WP_107380448.1 hypothetical protein -
C9J74_RS18980 4074562..4075164 + 603 WP_049443951.1 lipocalin family protein -
C9J74_RS18985 4075205..4075504 - 300 WP_049443949.1 HigA family addiction module antidote protein Antitoxin
C9J74_RS18990 4075514..4075792 - 279 WP_080354792.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9J74_RS18995 4076029..4076718 - 690 WP_049399224.1 ABC transporter permease -
C9J74_RS19000 4076715..4077722 - 1008 WP_107380450.1 methionine ABC transporter ATP-binding protein -
C9J74_RS19005 4077922..4078818 - 897 WP_049443945.1 DMT family transporter -
C9J74_RS19010 4079037..4079519 + 483 WP_006471121.1 YajQ family cyclic di-GMP-binding protein -
C9J74_RS19015 4079554..4080651 - 1098 WP_107380850.1 Fis family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10685.19 Da        Isoelectric Point: 10.3074

>T101031 WP_080354792.1 NZ_CP028358:c4075792-4075514 [Stenotrophomonas maltophilia]
MIRSFRCKQTRALFEGTCARAWRPIRRAAERKLQLLDSAQTLAFLRSPPGNRLEALSGDRKGQYSLRINDQWRLCFTWTD
NGADAVEIVDYH

Download         Length: 279 bp

>T101031 NZ_CP028358:c4075792-4075514 [Stenotrophomonas maltophilia]
ATGATTCGTTCATTCCGCTGCAAGCAGACCCGTGCCCTGTTTGAAGGAACCTGCGCTCGCGCCTGGCGCCCGATACGACG
CGCTGCCGAACGAAAACTCCAACTGCTCGACTCGGCGCAGACGTTGGCGTTCCTGCGCAGCCCCCCCGGAAACCGGCTCG
AAGCACTGTCAGGTGACCGGAAGGGGCAGTACAGCCTTCGAATCAACGATCAGTGGCGACTCTGCTTTACCTGGACCGAC
AACGGCGCCGATGCCGTGGAAATTGTTGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10876.54 Da        Isoelectric Point: 10.7753

>AT101031 WP_049443949.1 NZ_CP028358:c4075504-4075205 [Stenotrophomonas maltophilia]
MKHPHNGMRAIHPGEILREEFLLPLALSVNALARALDVPATRLHAIVHGERGISADTAARLARHFGGDAASWLAMQAAYD
LKTLPTRNEIERRVQPRAA

Download         Length: 300 bp

>AT101031 NZ_CP028358:c4075504-4075205 [Stenotrophomonas maltophilia]
ATGAAGCATCCCCACAACGGCATGCGCGCCATTCATCCTGGCGAGATCCTGCGCGAAGAGTTCCTGCTGCCGCTTGCGTT
GAGCGTGAACGCGCTTGCAAGGGCCTTGGACGTTCCCGCAACGCGGCTGCACGCCATCGTGCATGGCGAACGCGGCATCT
CGGCGGACACGGCCGCGCGGCTGGCGCGGCATTTCGGTGGGGATGCCGCATCCTGGCTTGCGATGCAGGCGGCTTACGAT
CTCAAGACATTACCAACGCGCAACGAGATCGAGCGACGAGTGCAGCCGCGGGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References