100989

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 391380..392010 Replicon chromosome
Accession NZ_CP028339
Organism Thauera aromatica K172

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Tharo_RS01885 Protein ID WP_107219754.1
Coordinates 391684..392010 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Tharo_RS01880 Protein ID WP_107219753.1
Coordinates 391380..391691 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Tharo_RS17520 386643..387377 + 735 WP_159051645.1 hypothetical protein -
Tharo_RS01850 387433..387759 - 327 WP_107219748.1 putative addiction module antidote protein -
Tharo_RS01855 387686..388024 - 339 WP_107222274.1 type II toxin-antitoxin system RelE/ParE family toxin -
Tharo_RS01860 388071..389696 - 1626 WP_107219749.1 IS66 family transposase -
Tharo_RS01865 389726..390085 - 360 WP_107219750.1 IS66 family insertion sequence element accessory protein TnpB -
Tharo_RS01870 390085..390390 - 306 WP_107219751.1 IS66 family insertion sequence hypothetical protein -
Tharo_RS01875 390627..391316 + 690 WP_159051646.1 DUF4351 domain-containing protein -
Tharo_RS01880 391380..391691 - 312 WP_107219753.1 helix-turn-helix domain-containing protein Antitoxin
Tharo_RS01885 391684..392010 - 327 WP_107219754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Tharo_RS01890 392175..392513 - 339 Protein_370 type II toxin-antitoxin system HicB family antitoxin -
Tharo_RS17705 392820..393044 + 225 Protein_371 Rpn family recombination-promoting nuclease/putative transposase -
Tharo_RS01900 393371..394396 + 1026 WP_107219756.1 Rpn family recombination-promoting nuclease/putative transposase -
Tharo_RS17630 394419..394646 - 228 WP_170109998.1 hypothetical protein -
Tharo_RS01905 394643..394990 - 348 WP_107219757.1 DNA-binding protein -
Tharo_RS01910 394971..395267 - 297 WP_211309648.1 hypothetical protein -
Tharo_RS01915 395402..395827 - 426 WP_107219759.1 type II toxin-antitoxin system HicB family antitoxin -
Tharo_RS01920 395839..396009 - 171 WP_107219760.1 type II toxin-antitoxin system HicA family toxin -
Tharo_RS01925 396445..396636 + 192 WP_107219761.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 387433..397640 10207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12606.66 Da        Isoelectric Point: 9.0634

>T100989 WP_107219754.1 NZ_CP028339:c392010-391684 [Thauera aromatica K172]
MNWAVSYFNERVQREITEWPVGIYADYLRLLLLMEEHGADLRLPHSRAMGDGLFELRCKGAEGIGRAFYCTMVGREIVIL
HSFIKKTQETPDRELKTARKRLKEVKHA

Download         Length: 327 bp

>T100989 NZ_CP028339:c392010-391684 [Thauera aromatica K172]
ATGAACTGGGCTGTCAGCTACTTCAATGAGCGCGTGCAACGCGAGATCACCGAGTGGCCGGTTGGCATCTACGCCGACTA
CCTTCGCCTGCTCCTACTAATGGAAGAGCACGGTGCCGACCTACGTTTGCCGCACTCACGTGCCATGGGCGACGGACTCT
TCGAGTTACGTTGCAAGGGCGCGGAAGGAATTGGCCGTGCGTTCTACTGCACGATGGTCGGACGCGAGATCGTGATCCTG
CACAGCTTTATCAAGAAGACGCAGGAAACGCCCGATCGGGAACTGAAAACAGCCCGCAAGCGACTGAAGGAGGTCAAACA
TGCATAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11552.30 Da        Isoelectric Point: 10.2589

>AT100989 WP_107219753.1 NZ_CP028339:c391691-391380 [Thauera aromatica K172]
MHSEQFKPVRLDTKAELARAMQRPGFKAAWDGLEEEYAALNELLQARKQAGLTQEEVAARMGTTKSAVSRLEASIRSEHH
SPSFATLRKYAHACGKRLIIKMV

Download         Length: 312 bp

>AT100989 NZ_CP028339:c391691-391380 [Thauera aromatica K172]
ATGCATAGCGAGCAATTCAAGCCGGTTCGCCTGGACACCAAGGCGGAACTTGCCCGTGCCATGCAACGGCCAGGATTCAA
GGCCGCGTGGGACGGATTGGAAGAGGAGTACGCTGCACTCAACGAACTGCTGCAGGCCCGCAAGCAGGCGGGCCTGACCC
AAGAGGAAGTCGCAGCCCGCATGGGAACGACCAAGAGTGCCGTGTCGCGCCTGGAAGCCTCGATCCGCAGCGAGCACCAT
TCGCCCTCGTTCGCCACGCTGCGCAAGTACGCACATGCCTGCGGCAAGCGCCTGATCATCAAGATGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References