Detailed information of TA system TA100985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 17248..17750
• Replicon: chromosome
• Accession: NZ_CP028339
• Organism: Thauera aromatica K172

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: Tharo_RS00055
• Protein ID: WP_107219446.1
• Coordinates: 17487..17750 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: C4ZIF2
• Locus tag: Tharo_RS00050
• Protein ID: WP_012584201.1
• Coordinates: 17248..17490 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Tharo_RS00035	12809..14920	+	2112	WP_107219443.1	DEAD/DEAH box helicase	-
Tharo_RS00040	15237..15848	+	612	WP_107219444.1	hypothetical protein	-
Tharo_RS00045	15845..17035	+	1191	WP_107219445.1	DUF2157 domain-containing protein	-
Tharo_RS00050	17248..17490	+	243	WP_012584201.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Tharo_RS00055	17487..17750	+	264	WP_107219446.1	Txe/YoeB family addiction module toxin	Toxin
Tharo_RS00060	17898..18167	+	270	WP_107219447.1	ribbon-helix-helix domain-containing protein	-
Tharo_RS00065	18167..18445	+	279	WP_107219448.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Tharo_RS00070	18563..19396	-	834	WP_107219449.1	hypothetical protein	-
Tharo_RS00075	19411..20283	-	873	WP_107222251.1	hypothetical protein	-
Tharo_RS00090	20960..21424	+	465	WP_107219452.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (24-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9964.48 Da
• Isoelectric Point: 9.8344

>T100985 WP_107219446.1 NZ_CP028339:17487-17750 [Thauera aromatica K172]
VSWQLVFSNHAQKDAKKLAAAGLKSKAQDLLAILANDPFQTPPPYEKLVGDLAGAYSRRINIQHRLVYEVFAEERVVRVL
RMWSHYE

Nucleotide

• Length: 264 bp

>T100985 NZ_CP028339:17487-17750 [Thauera aromatica K172]
GTGAGCTGGCAGCTCGTGTTCTCGAACCACGCCCAGAAGGACGCGAAGAAGCTGGCGGCCGCCGGCCTGAAGTCGAAGGC
CCAGGACTTGCTCGCGATCCTGGCGAATGATCCCTTCCAGACGCCCCCGCCCTACGAGAAGCTCGTGGGCGACCTTGCCG
GGGCCTACTCGCGCCGGATCAACATCCAGCACCGCCTGGTCTATGAGGTCTTCGCCGAGGAGCGCGTGGTTCGCGTGCTG
AGGATGTGGTCGCATTACGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8914.05 Da
• Isoelectric Point: 4.5778

>AT100985 WP_012584201.1 NZ_CP028339:17248-17490 [Thauera aromatica K172]
MTTLTASEARANLYRLIDQAAESHQPIHIAGKRTSAVLLSAEDWQAIQETLHLLSIPGMRESIKEGMAEPLDESARELDW

Nucleotide

• Length: 243 bp

>AT100985 NZ_CP028339:17248-17490 [Thauera aromatica K172]
ATGACCACGCTCACCGCTTCCGAGGCACGGGCCAACCTGTACCGCCTCATCGATCAGGCCGCAGAGTCCCATCAGCCCAT
TCACATCGCGGGCAAGCGCACGAGCGCCGTCTTGCTCTCCGCGGAAGACTGGCAGGCCATCCAGGAAACGCTTCACCTGC
TTTCCATCCCGGGGATGCGCGAGTCCATCAAGGAGGGCATGGCCGAGCCGCTTGACGAGAGCGCCCGGGAGCTCGACTGG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0C3N9L8