Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 962242..962500 Replicon chromosome
Accession NZ_CP028320
Organism Escherichia coli O18:H1 strain CFSAN067215

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C7X15_RS04685 Protein ID WP_000809168.1
Coordinates 962242..962394 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 962443..962500 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7X15_RS04665 957487..958200 - 714 WP_001102391.1 acidic protein MsyB -
C7X15_RS04670 958226..958630 - 405 WP_000843687.1 DUF2541 family protein -
C7X15_RS04675 959002..960918 + 1917 WP_000516135.1 molecular chaperone DnaK -
C7X15_RS04680 961007..962137 + 1131 WP_001118464.1 molecular chaperone DnaJ -
C7X15_RS04685 962242..962394 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 962443..962500 + 58 - - Antitoxin
C7X15_RS04690 963009..963770 + 762 WP_001274832.1 hypothetical protein -
C7X15_RS04695 963790..965283 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
C7X15_RS04700 965412..966671 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T100960 WP_000809168.1 NZ_CP028320:c962394-962242 [Escherichia coli O18:H1]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T100960 NZ_CP028320:c962394-962242 [Escherichia coli O18:H1]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT100960 NZ_CP028320:962443-962500 [Escherichia coli O18:H1]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References