Detailed information of TA system TA100950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 36480..37137
• Replicon: plasmid pSC-31-2
• Accession: NZ_CP028316
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium var. 5- strain CFSAN067217

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: C7X12_RS24995
• Protein ID: WP_000270043.1
• Coordinates: 36480..36830 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: C7X12_RS25000
• Protein ID: WP_000124640.1
• Coordinates: 36835..37137 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7X12_RS24955	33086..33439	-	354	Protein_46	hypothetical protein	-
C7X12_RS24960	33442..33930	-	489	WP_001273096.1	DUF1643 domain-containing protein	-
C7X12_RS24965	34027..34383	+	357	WP_020833609.1	hypothetical protein	-
C7X12_RS24970	34392..34862	-	471	WP_001281821.1	hypothetical protein	-
C7X12_RS24975	34855..35226	-	372	WP_020833608.1	hypothetical protein	-
C7X12_RS24980	35234..35428	-	195	WP_000343597.1	hypothetical protein	-
C7X12_RS24990	35769..36317	-	549	WP_001061574.1	transcriptional regulator	-
C7X12_RS24995	36480..36830	+	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
C7X12_RS25000	36835..37137	+	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
C7X12_RS25005	37165..37458	-	294	WP_020833606.1	chromosome segregation protein ParM	-
C7X12_RS25010	37547..37819	-	273	WP_020833605.1	HU family DNA-binding protein	-
C7X12_RS25015	37877..38404	-	528	WP_020833604.1	thermonuclease family protein	-
C7X12_RS25025	38635..39492	-	858	WP_020833602.1	hypothetical protein	-
C7X12_RS25030	39479..39709	-	231	WP_020833601.1	hypothetical protein	-
C7X12_RS25035	39709..40227	-	519	WP_020833600.1	hypothetical protein	-
C7X12_RS25040	40224..40670	-	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
C7X12_RS25045	40670..41029	-	360	WP_000422768.1	hypothetical protein	-
C7X12_RS25050	41086..41514	-	429	WP_000591074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..187594	187594

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 15014.38 Da
• Isoelectric Point: 12.8644

>T100950 WP_000270043.1 NZ_CP028316:36480-36830 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 351 bp

>T100950 NZ_CP028316:36480-36830 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 12963.60 Da
• Isoelectric Point: 12.8000

>AT100950 WP_000124640.1 NZ_CP028316:36835-37137 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 303 bp

>AT100950 NZ_CP028316:36835-37137 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A7G8AFB9