Detailed information of TA system TA100936

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 144118..144455
• Replicon: chromosome
• Accession: NZ_CP028285
• Organism: Enterococcus faecalis strain FDAARGOS_324

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: CEQ02_RS01435
• Protein ID: WP_002381035.1
• Coordinates: 144312..144455 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	144118..144380 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CEQ02_RS01430	141121..144117	+	2997	WP_002385134.1	WxL domain-containing protein	-
-	144118..144380	+	263	-	-	Antitoxin
CEQ02_RS01435	144312..144455	-	144	WP_002381035.1	putative holin-like toxin	Toxin
CEQ02_RS01440	144785..146401	-	1617	WP_107164636.1	phosphatase PAP2/LCP family protein	-
CEQ02_RS01450	147089..147727	+	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
CEQ02_RS01455	147991..148983	-	993	WP_002385136.1	biotin--[acetyl-CoA-carboxylase] ligase	-
CEQ02_RS01460	149122..149337	+	216	WP_002354768.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T100936 WP_002381035.1 NZ_CP028285:c144455-144312 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T100936 NZ_CP028285:c144455-144312 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT100936 NZ_CP028285:144118-144380 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin