Detailed information of TA system TA100878

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): bsrG-as-bsrE/-
• Location: 494428..494592
• Replicon: chromosome
• Accession: NZ_CP028212
• Organism: Bacillus subtilis strain SRCM102748

Toxin (Protein)

• Gene name: bsrG
• Uniprot ID: L8EAY0
• Locus tag: C7M26_RS02940
• Protein ID: WP_009967548.1
• Coordinates: 494476..494592 (-)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	as-bsrE
Locus tag	-
Coordinates	494428..494481 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7M26_RS02910	489446..489919	+	474	WP_109962772.1	hypothetical protein	-
C7M26_RS02915	489962..490846	-	885	WP_109962771.1	endonuclease YokF	-
C7M26_RS02920	491026..491276	+	251	Protein_582	hypothetical protein	-
C7M26_RS02925	491361..491894	+	534	WP_109962770.1	SMI1/KNR4 family protein	-
C7M26_RS02930	492027..493913	+	1887	WP_109962769.1	HNH endonuclease	-
C7M26_RS02935	493926..494384	+	459	WP_109962768.1	SMI1/KNR4 family protein	-
-	494428..494481	+	54	NuclAT_2	-	Antitoxin
-	494428..494481	+	54	NuclAT_2	-	Antitoxin
-	494428..494481	+	54	NuclAT_2	-	Antitoxin
-	494428..494481	+	54	NuclAT_2	-	Antitoxin
C7M26_RS02940	494476..494592	-	117	WP_009967548.1	type I toxin-antitoxin system toxin BsrG	Toxin
C7M26_RS02945	494853..495212	+	360	WP_041338710.1	hypothetical protein	-
C7M26_RS02950	495256..495591	-	336	WP_041054825.1	hypothetical protein	-
C7M26_RS02955	495765..496097	+	333	WP_114168637.1	YolD-like family protein	-
C7M26_RS02960	496090..497340	+	1251	WP_114168635.1	UV damage repair protein UvrX	-
C7M26_RS02965	497381..497557	-	177	WP_019712878.1	hypothetical protein	-
C7M26_RS02970	497547..498683	-	1137	WP_114168633.1	tetratricopeptide repeat protein	-
C7M26_RS02975	498810..499061	-	252	WP_114168631.1	phage holin	-
C7M26_RS02980	499082..499474	-	393	WP_010328137.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	486635..616393	129758

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-38)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4336.39 Da
• Isoelectric Point: 10.1022

>T100878 WP_009967548.1 NZ_CP028212:c494592-494476 [Bacillus subtilis]
MTVYESLMIMINFGGLILNTVLLIFNIMMIVTSSQKKK

Nucleotide

• Length: 117 bp

>T100878 NZ_CP028212:c494592-494476 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin

Nucleotide

• Length: 54 bp

>AT100878 NZ_CP028212:494428-494481 [Bacillus subtilis]
AAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAAACTCAAGGGAAGGTCTATTT

Structures

Toxin

• AlphaFold DB: A0A7Z7EVU9

Antitoxin