Detailed information of TA system TA100805

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1233391..1233970
• Replicon: chromosome
• Accession: NZ_CP028190
• Organism: Staphylococcus aureus strain CFSAN018749

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: C9J86_RS06335
• Protein ID: WP_001025401.1
• Coordinates: 1233391..1233636 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1233605..1233970 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9J86_RS06290	1229375..1229989	+	615	WP_000191459.1	hypothetical protein	-
C9J86_RS06295	1229986..1230132	-	147	WP_078098954.1	hypothetical protein	-
C9J86_RS06300	1230168..1230351	-	184	Protein_1188	hypothetical protein	-
C9J86_RS06305	1230447..1231367	-	921	WP_000348133.1	3'-5' exoribonuclease	-
C9J86_RS06310	1231383..1231997	-	615	WP_000801423.1	XRE family transcriptional regulator	-
C9J86_RS06315	1232169..1232396	+	228	WP_001030311.1	hypothetical protein	-
C9J86_RS06320	1232422..1232977	+	556	Protein_1192	phage antirepressor KilAC domain-containing protein	-
C9J86_RS06325	1232993..1233136	+	144	WP_000939498.1	hypothetical protein	-
C9J86_RS06330	1233126..1233335	-	210	WP_000642492.1	hypothetical protein	-
C9J86_RS06335	1233391..1233636	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
C9J86_RS06340	1233605..1233970	-	366	WP_016170627.1	hypothetical protein	Antitoxin
C9J86_RS06345	1234025..1234240	+	216	WP_001097552.1	hypothetical protein	-
C9J86_RS06350	1234265..1234528	+	264	WP_015994740.1	helix-turn-helix domain-containing protein	-
C9J86_RS06355	1234540..1234701	+	162	WP_001285949.1	DUF1270 domain-containing protein	-
C9J86_RS06360	1234783..1235106	+	324	WP_069990202.1	TrmB family transcriptional regulator	-
C9J86_RS06365	1235121..1235483	+	363	WP_031775792.1	hypothetical protein	-
C9J86_RS06370	1235480..1236646	+	1167	WP_107285518.1	DUF2800 domain-containing protein	-
C9J86_RS06375	1236673..1237227	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1228044..1272469	44425

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T100805 WP_001025401.1 NZ_CP028190:1233391-1233636 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T100805 NZ_CP028190:1233391-1233636 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT100805 NZ_CP028190:c1233970-1233605 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin