100791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1386271..1386788 Replicon chromosome
Accession NZ_CP028189
Organism Staphylococcus aureus strain CFSAN018750

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag C9J90_RS07235 Protein ID WP_000113262.1
Coordinates 1386271..1386537 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag C9J90_RS07240 Protein ID WP_000584499.1
Coordinates 1386537..1386788 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J90_RS07210 1381696..1382232 - 537 WP_031585827.1 GNAT family N-acetyltransferase -
C9J90_RS07215 1382465..1383289 - 825 WP_000572040.1 formate/nitrite transporter family protein -
C9J90_RS07220 1383506..1383688 - 183 WP_000230294.1 hypothetical protein -
C9J90_RS07225 1383772..1384239 - 468 WP_000153344.1 SRPBCC domain-containing protein -
C9J90_RS07230 1384425..1385975 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
C9J90_RS07235 1386271..1386537 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
C9J90_RS07240 1386537..1386788 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C9J90_RS07245 1386953..1387054 - 102 WP_031774922.1 hypothetical protein -
C9J90_RS07250 1387061..1387660 - 600 WP_000162813.1 DsbA family protein -
C9J90_RS07255 1387679..1388041 - 363 WP_000819843.1 DUF4467 domain-containing protein -
C9J90_RS07260 1388296..1389546 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
C9J90_RS07265 1389643..1390374 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
C9J90_RS07270 1390371..1391090 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T100791 WP_000113262.1 NZ_CP028189:c1386537-1386271 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T100791 NZ_CP028189:c1386537-1386271 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT100791 WP_000584499.1 NZ_CP028189:c1386788-1386537 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT100791 NZ_CP028189:c1386788-1386537 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References