Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1193243..1193760 Replicon chromosome
Accession NZ_CP028165
Organism Staphylococcus aureus strain CFSAN064037

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag C9J78_RS06240 Protein ID WP_000113259.1
Coordinates 1193243..1193509 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C9J78_RS06245 Protein ID WP_000584500.1
Coordinates 1193509..1193760 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9J78_RS06215 1188413..1188949 - 537 WP_000185899.1 GNAT family N-acetyltransferase -
C9J78_RS06220 1189449..1190273 - 825 WP_000594633.1 formate/nitrite transporter family protein -
C9J78_RS06225 1190476..1190658 - 183 WP_000079140.1 hypothetical protein -
C9J78_RS06230 1190745..1191212 - 468 WP_000153340.1 SRPBCC domain-containing protein -
C9J78_RS06235 1191398..1192948 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
C9J78_RS06240 1193243..1193509 - 267 WP_000113259.1 Txe/YoeB family addiction module toxin Toxin
C9J78_RS06245 1193509..1193760 - 252 WP_000584500.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C9J78_RS06250 1193924..1194022 - 99 Protein_1148 hypothetical protein -
C9J78_RS06255 1194032..1194631 - 600 WP_000162810.1 DsbA family protein -
C9J78_RS06260 1194650..1195012 - 363 WP_000819848.1 DUF4467 domain-containing protein -
C9J78_RS06265 1195267..1196517 + 1251 WP_001012232.1 FemA/FemB family glycyltransferase FmhA -
C9J78_RS06270 1196614..1197345 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
C9J78_RS06275 1197342..1198061 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10464.08 Da        Isoelectric Point: 10.2538

>T100723 WP_000113259.1 NZ_CP028165:c1193509-1193243 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T100723 NZ_CP028165:c1193509-1193243 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9419.58 Da        Isoelectric Point: 4.3407

>AT100723 WP_000584500.1 NZ_CP028165:c1193760-1193509 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT100723 NZ_CP028165:c1193760-1193509 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References