Detailed information of TA system TA100711

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1282751..1283089
• Replicon: chromosome
• Accession: NZ_CP028163
• Organism: Staphylococcus aureus strain CFSAN064038

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: C9J77_RS06645
• Protein ID: WP_011447039.1
• Coordinates: 1282751..1282927 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1282915..1283089 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9J77_RS06625	1277986..1281771	+	3786	WP_000582186.1	hypothetical protein	-
C9J77_RS06630	1281761..1281913	+	153	WP_001153681.1	hypothetical protein	-
C9J77_RS06635	1281960..1282247	+	288	WP_001040261.1	hypothetical protein	-
C9J77_RS06640	1282305..1282601	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
C9J77_RS06645	1282751..1282927	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1282915..1283089	-	175	-	-	Antitoxin
C9J77_RS06655	1283139..1283393	+	255	WP_000611512.1	phage holin	-
C9J77_RS06660	1283405..1284160	+	756	WP_000861038.1	CHAP domain-containing protein	-
C9J77_RS06665	1284351..1284842	+	492	WP_000920041.1	staphylokinase	-
C9J77_RS06670	1285453..1285803	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
C9J77_RS06675	1285856..1286116	-	261	WP_001791826.1	hypothetical protein	-
C9J77_RS06685	1286427..1286606	-	180	WP_000669789.1	hypothetical protein	-
C9J77_RS06690	1286928..1287175	-	248	Protein_1257	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / scn	1234358..1285803	51445

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T100711 WP_011447039.1 NZ_CP028163:1282751-1282927 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T100711 NZ_CP028163:1282751-1282927 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT100711 NZ_CP028163:c1283089-1282915 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin