Detailed information of TA system TA100699

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 134245..134824
• Replicon: chromosome
• Accession: NZ_CP028163
• Organism: Staphylococcus aureus strain CFSAN064038

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: C9J77_RS00825
• Protein ID: WP_001025401.1
• Coordinates: 134579..134824 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	134245..134610 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C9J77_RS00785	130987..131544	-	558	WP_000645049.1	DUF2815 family protein	-
C9J77_RS00790	131571..132737	-	1167	WP_031794996.1	DUF2800 domain-containing protein	-
C9J77_RS00795	132734..133096	-	363	WP_000985976.1	hypothetical protein	-
C9J77_RS00800	133111..133434	-	324	WP_000174994.1	hypothetical protein	-
C9J77_RS00805	133513..133674	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
C9J77_RS00810	133687..133950	-	264	WP_016187436.1	helix-turn-helix domain-containing protein	-
C9J77_RS00815	133975..134190	-	216	WP_001097552.1	hypothetical protein	-
C9J77_RS00820	134245..134610	+	366	WP_016170627.1	hypothetical protein	Antitoxin
C9J77_RS00825	134579..134824	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
C9J77_RS00830	134880..135089	+	210	WP_000642492.1	hypothetical protein	-
C9J77_RS00835	135079..135222	-	144	WP_000939498.1	hypothetical protein	-
C9J77_RS00840	135251..136027	-	777	WP_001148544.1	Rha family transcriptional regulator	-
C9J77_RS00845	136041..136277	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
C9J77_RS00850	136429..136743	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
C9J77_RS00855	136756..137217	+	462	WP_000525004.1	hypothetical protein	-
C9J77_RS00860	137235..137819	+	585	WP_031918390.1	hypothetical protein	-
C9J77_RS00865	138050..138196	+	147	WP_074370993.1	hypothetical protein	-
C9J77_RS00870	138193..138807	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	94924..149382	54458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T100699 WP_001025401.1 NZ_CP028163:c134824-134579 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T100699 NZ_CP028163:c134824-134579 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT100699 NZ_CP028163:134245-134610 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin