Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5268028..5268623 Replicon chromosome
Accession NZ_CP028132
Organism Pseudomonas aeruginosa strain YB01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C7T90_RS24395 Protein ID WP_079380683.1
Coordinates 5268345..5268623 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C7T90_RS24390 Protein ID WP_003099268.1
Coordinates 5268028..5268333 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7T90_RS24355 5263179..5264027 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
C7T90_RS24365 5264194..5265135 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
C7T90_RS24370 5265252..5265866 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
C7T90_RS24375 5265908..5266492 + 585 WP_033943274.1 aminoacyl-tRNA hydrolase -
C7T90_RS24380 5266533..5267633 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
C7T90_RS24390 5268028..5268333 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
C7T90_RS24395 5268345..5268623 - 279 WP_079380683.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7T90_RS24400 5268952..5271180 + 2229 WP_028680758.1 TonB-dependent receptor -
C7T90_RS24405 5271250..5271897 - 648 WP_003095021.1 carbonate dehydratase -
C7T90_RS24410 5271959..5273197 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T100673 WP_079380683.1 NZ_CP028132:c5268623-5268345 [Pseudomonas aeruginosa]
MILTFRCDETRQLFEAGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T100673 NZ_CP028132:c5268623-5268345 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGGCGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT100673 WP_003099268.1 NZ_CP028132:c5268333-5268028 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT100673 NZ_CP028132:c5268333-5268028 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References