Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4598419..4599100 Replicon chromosome
Accession NZ_CP028132
Organism Pseudomonas aeruginosa strain YB01

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag C7T90_RS21260 Protein ID WP_003111825.1
Coordinates 4598735..4599100 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag C7T90_RS21255 Protein ID WP_003159602.1
Coordinates 4598419..4598742 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7T90_RS21220 4593675..4594553 + 879 WP_009315285.1 hypothetical protein -
C7T90_RS21230 4595183..4596892 + 1710 WP_073666786.1 TIGR04141 family sporadically distributed protein -
C7T90_RS21235 4596878..4597414 - 537 WP_073655295.1 tyrosine-type recombinase/integrase -
C7T90_RS21240 4597522..4597797 - 276 WP_004353146.1 hypothetical protein -
C7T90_RS21245 4597797..4598129 - 333 WP_021205399.1 hypothetical protein -
C7T90_RS21250 4598184..4598303 + 120 Protein_4200 IS5/IS1182 family transposase -
C7T90_RS21255 4598419..4598742 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
C7T90_RS21260 4598735..4599100 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7T90_RS21265 4599393..4599653 - 261 WP_073666792.1 hypothetical protein -
C7T90_RS21270 4599860..4600132 + 273 WP_014603216.1 hypothetical protein -
C7T90_RS21275 4600162..4600587 - 426 WP_033943491.1 VOC family protein -
C7T90_RS21280 4600688..4601572 + 885 WP_033943492.1 LysR family transcriptional regulator -
C7T90_RS21285 4601545..4602498 - 954 WP_003085661.1 LysR family transcriptional regulator -
C7T90_RS21290 4602719..4603153 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T100672 WP_003111825.1 NZ_CP028132:c4599100-4598735 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

>T100672 NZ_CP028132:c4599100-4598735 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCATG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGATCCCAGACGCTCCGCG
ATACTGCTGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCTATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT100672 WP_003159602.1 NZ_CP028132:c4598742-4598419 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT100672 NZ_CP028132:c4598742-4598419 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGGACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGGCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCACGTGC
AGCAGCCGGCAATTGCCAAAATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAACTGGAAGTGATTGCACGCTTCCCGGATGGCGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCGGGCGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References