Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DhiAT/- |
| Location | 1676268..1677022 | Replicon | chromosome |
| Accession | NC_014500 | ||
| Organism | Dickeya dadantii 3937 | ||
Toxin (Protein)
| Gene name | dhiT | Uniprot ID | - |
| Locus tag | DDA3937_RS07415 | Protein ID | WP_033111742.1 |
| Coordinates | 1676268..1676525 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | dhiA | Uniprot ID | - |
| Locus tag | DDA3937_RS07420 | Protein ID | WP_033111743.1 |
| Coordinates | 1676534..1677022 (+) | Length | 163 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DDA3937_RS07405 (Dda3937_00742) | 1673030..1675180 | - | 2151 | WP_013317224.1 | formate dehydrogenase subunit alpha | - |
| DDA3937_RS07410 (Dda3937_00741) | 1675215..1675757 | - | 543 | WP_013317225.1 | 4Fe-4S dicluster domain-containing protein | - |
| DDA3937_RS07415 (Dda3937_00739) | 1676268..1676525 | + | 258 | WP_033111742.1 | DUF4160 domain-containing protein | Toxin |
| DDA3937_RS07420 (Dda3937_00738) | 1676534..1677022 | + | 489 | WP_033111743.1 | DUF2442 domain-containing protein | Antitoxin |
| DDA3937_RS07425 (Dda3937_00737) | 1677098..1677592 | - | 495 | WP_013317229.1 | hydrogenase maturation peptidase HycI | - |
| DDA3937_RS07430 (Dda3937_00736) | 1677585..1677983 | - | 399 | WP_013317230.1 | formate hydrogenlyase maturation HycH family protein | - |
| DDA3937_RS07435 (Dda3937_00735) | 1677980..1678771 | - | 792 | WP_013317231.1 | NADH-quinone oxidoreductase subunit B family protein | - |
| DDA3937_RS07440 (Dda3937_00734) | 1678768..1679337 | - | 570 | WP_013317232.1 | hydrogenase 4 subunit H | - |
| DDA3937_RS07445 (Dda3937_00733) | 1679348..1681075 | - | 1728 | WP_013317233.1 | hydrogenase large subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9972.56 Da Isoelectric Point: 7.5550
>T10066 WP_033111742.1 NC_014500:1676268-1676525 [Dickeya dadantii 3937]
MPEIDRLAGLIFYLYFYDDGRHHQPHVHVCYGDDELIIAIDTGIEIEGYLPNSKRKMAIRHINAHRQHLLEMWKLAVKGR
HPGKL
MPEIDRLAGLIFYLYFYDDGRHHQPHVHVCYGDDELIIAIDTGIEIEGYLPNSKRKMAIRHINAHRQHLLEMWKLAVKGR
HPGKL
Download Length: 258 bp
>T10066 NC_014500:1676268-1676525 [Dickeya dadantii 3937]
ATGCCTGAAATTGACAGACTGGCAGGGCTCATTTTCTATCTGTATTTTTACGATGATGGCAGGCACCACCAGCCTCATGT
GCATGTCTGTTACGGTGATGATGAGTTGATCATCGCGATAGATACAGGCATTGAGATCGAAGGCTATTTGCCCAATAGCA
AGCGTAAGATGGCGATTAGGCATATCAACGCGCATCGGCAACATTTGCTGGAAATGTGGAAACTGGCAGTGAAAGGCCGT
CATCCGGGAAAATTGTGA
ATGCCTGAAATTGACAGACTGGCAGGGCTCATTTTCTATCTGTATTTTTACGATGATGGCAGGCACCACCAGCCTCATGT
GCATGTCTGTTACGGTGATGATGAGTTGATCATCGCGATAGATACAGGCATTGAGATCGAAGGCTATTTGCCCAATAGCA
AGCGTAAGATGGCGATTAGGCATATCAACGCGCATCGGCAACATTTGCTGGAAATGTGGAAACTGGCAGTGAAAGGCCGT
CATCCGGGAAAATTGTGA
Antitoxin
Download Length: 163 a.a. Molecular weight: 17862.40 Da Isoelectric Point: 6.9789
>AT10066 WP_033111743.1 NC_014500:1676534-1677022 [Dickeya dadantii 3937]
MHKIIDVDVTGDFSLRLTYEDGLICDVDLYQYAPGPVFSNASLFIKFGLLPDGALEWQPDIKISASDLRKKGVYVGHTLA
VRERHFADVISRAFYDAVIENRPEILQAALKTAVDKHGNSTVAKEAGAKSRTSLYKSLNKNTNVSLATVVSLAHTVLQLE
EK
MHKIIDVDVTGDFSLRLTYEDGLICDVDLYQYAPGPVFSNASLFIKFGLLPDGALEWQPDIKISASDLRKKGVYVGHTLA
VRERHFADVISRAFYDAVIENRPEILQAALKTAVDKHGNSTVAKEAGAKSRTSLYKSLNKNTNVSLATVVSLAHTVLQLE
EK
Download Length: 489 bp
>AT10066 NC_014500:1676534-1677022 [Dickeya dadantii 3937]
ATGCATAAAATCATCGATGTTGATGTGACTGGTGACTTTTCCTTGCGGCTGACCTATGAGGACGGCTTGATCTGTGATGT
CGATCTTTACCAATACGCCCCTGGTCCGGTGTTTTCGAACGCCAGCCTATTTATCAAGTTTGGCCTGTTGCCGGATGGCG
CGCTGGAATGGCAGCCGGATATTAAGATTTCCGCGTCAGACTTGCGGAAAAAAGGCGTGTATGTCGGCCACACGCTGGCG
GTGCGAGAAAGGCACTTCGCTGATGTTATCTCTCGCGCCTTCTATGACGCCGTGATTGAGAACCGGCCGGAAATTCTGCA
GGCGGCGCTGAAAACCGCAGTAGACAAACATGGCAACAGTACGGTGGCCAAAGAAGCGGGAGCCAAAAGCCGTACCAGCC
TGTATAAGTCGCTGAATAAAAACACTAATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGTTACAACTGGAA
GAGAAGTAG
ATGCATAAAATCATCGATGTTGATGTGACTGGTGACTTTTCCTTGCGGCTGACCTATGAGGACGGCTTGATCTGTGATGT
CGATCTTTACCAATACGCCCCTGGTCCGGTGTTTTCGAACGCCAGCCTATTTATCAAGTTTGGCCTGTTGCCGGATGGCG
CGCTGGAATGGCAGCCGGATATTAAGATTTCCGCGTCAGACTTGCGGAAAAAAGGCGTGTATGTCGGCCACACGCTGGCG
GTGCGAGAAAGGCACTTCGCTGATGTTATCTCTCGCGCCTTCTATGACGCCGTGATTGAGAACCGGCCGGAAATTCTGCA
GGCGGCGCTGAAAACCGCAGTAGACAAACATGGCAACAGTACGGTGGCCAAAGAAGCGGGAGCCAAAAGCCGTACCAGCC
TGTATAAGTCGCTGAATAAAAACACTAATGTCAGCCTGGCGACGGTGGTCAGCCTGGCGCATACCGTGTTACAACTGGAA
GAGAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T10035 | Vibrio cholerae O1 biovar El Tor str. N16961 |
60 |
100 |
0.6 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10035 | Vibrio cholerae O1 biovar El Tor str. N16961 |
37.888 |
99.383 |
0.377 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Lidia Boss et al. (2021) Identification of Three Type II Toxin-Antitoxin Systems in Model Bacterial Plant Pathogen Dickeya dadantii 3937. International Journal of Molecular Sciences 22(11):5932. [PubMed:34073004]