Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yxiD-yxxD/- |
| Location | 4031591..4033740 | Replicon | chromosome |
| Accession | NZ_CP034484 | ||
| Organism | Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610 | ||
Toxin (Protein)
| Gene name | yxiD | Uniprot ID | P42296 |
| Locus tag | EJJ34_RS21365 | Protein ID | WP_003244234.1 |
| Coordinates | 4032031..4033740 (-) | Length | 570 a.a. |
Antitoxin (Protein)
| Gene name | yxxD | Uniprot ID | P40737 |
| Locus tag | EJJ34_RS21360 | Protein ID | WP_003244256.1 |
| Coordinates | 4031591..4032034 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EJJ34_RS21340 (EJJ34_21340) | 4027044..4027490 | - | 447 | WP_003227162.1 | universal stress protein | - |
| EJJ34_RS21345 (EJJ34_21345) | 4027593..4029002 | - | 1410 | WP_003243232.1 | aryl-phospho-beta-d-glucosidase | - |
| EJJ34_RS21350 (EJJ34_21350) | 4029025..4030854 | - | 1830 | WP_003242943.1 | PTS beta-glucoside transporter subunit IIABC | - |
| EJJ34_RS21355 (EJJ34_21355) | 4031237..4031545 | - | 309 | WP_003242733.1 | contact-dependent growth inhibition system immunity protein | - |
| EJJ34_RS21360 (EJJ34_21360) | 4031591..4032034 | - | 444 | WP_003244256.1 | type II toxin-antitoxin system antitoxin YxxD | Antitoxin |
| EJJ34_RS21365 (EJJ34_21365) | 4032031..4033740 | - | 1710 | WP_003244234.1 | LXG family T7SS effector ribonuclease toxin YxiD | Toxin |
| EJJ34_RS21370 (EJJ34_21370) | 4033760..4034029 | - | 270 | WP_003244193.1 | YwqI/YxiC family protein | - |
| EJJ34_RS21375 (EJJ34_21375) | 4034041..4034406 | - | 366 | WP_009968400.1 | DUF5082 family protein | - |
| EJJ34_RS21380 (EJJ34_21380) | 4034713..4036122 | - | 1410 | WP_003244268.1 | arabinan endo-1,5-alpha-L-arabinosidase AbnB | - |
| EJJ34_RS21385 (EJJ34_21385) | 4036256..4036420 | - | 165 | WP_009969160.1 | hypothetical protein | - |
| EJJ34_RS21390 (EJJ34_21390) | 4036738..4037184 | + | 447 | WP_003243875.1 | hut operon transcriptional regulator HutP | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 570 a.a. Molecular weight: 83908.68 Da Isoelectric Point: 5.5500
>T10057 WP_003244234.1 NZ_CP034484:c4033740-4032031 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDALKGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQ
TQHAISSVESNSHGMIAEAFLSHDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN
KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENINQIFGAINPQMKQADDSPMEMM
LKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVYNTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVS
LSDIKVDENGYVKILETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKLINNGKKAK
KASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQIDKLKEALRNKEYKKMSPIETAKHRTKFDK
VKNKVIKEWEENTGQKWPVYKENVVSEKTGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPAN
ELFKGGKKK
MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDALKGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQ
TQHAISSVESNSHGMIAEAFLSHDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN
KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENINQIFGAINPQMKQADDSPMEMM
LKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVYNTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVS
LSDIKVDENGYVKILETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKLINNGKKAK
KASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQIDKLKEALRNKEYKKMSPIETAKHRTKFDK
VKNKVIKEWEENTGQKWPVYKENVVSEKTGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPAN
ELFKGGKKK
Download Length: 1710 bp
>T10057 NZ_CP034484:c4033740-4032031 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
TTGAAAACATTAGATGTCCACGCTCTTCACGAGGGCATTCAGCATACGATTGAGAAACTGGACAAGCAAAAACAACAGCT
GGAGAAGCTGGAAAAAAGCGTTGAGCATCTGGCAGGCATGAAGGATGCGCTGAAAGGAAAAGGCGGAGATGCCATCCGGA
CCTTTTACGAGGAGTGCCACAAGCCTTTTCTCCTTTTCTTTGGCATATTTATCGACGAATACAAAAAAGTGCTGAAACAA
ACACAGCATGCGATTTCCTCTGTAGAATCTAACTCCCACGGCATGATCGCAGAGGCTTTTCTCTCACACGATGCGAGACA
TGGGGTCAAGCATGCACGAGAAGTGACAGAGCAGCTCACTGACGCAGTCAATCGCCAGACATCAGCCATAGATCACATCG
TCAGCCTGCCGACAGTCAATGATTCCTTTTTTCGGATGGAAACAGAACAGGCTGAGCGGCTGATTTCAGACACCCTGAAT
AAGCTCTTTCAATTTGACGGCCAGCAAACCCAAGCACTAGAAGCCGCAAAATCAGATTTTCAAACGATGAAAAAATACAT
TGATCAGCTCGAAACCATGTACACCGGCCCGAAAATTGAAATCACAGGCTACAAAAGCGGCTCCATCCTGAAATCACAGG
AAGAAGAAAACATCAACCAAATCTTCGGCGCGATTAACCCGCAAATGAAGCAGGCGGATGATTCACCGATGGAGATGATG
CTGAAGAAATTAGCCGAGAATGAAAAGTCTAAAGTGGATTCAGTTGTCAAAACGGGTGATTCTAAAAAGGTAAGTAAAAA
TATCATCGTTATCAATGGTAAAGTGTATAATACGAGTGAACATAGAGAACATATAAAAACTGATTTCTCAAATGCAGAGG
TTAAGCAAGTCGTTTATAATGATACACTTTACAATGTATACATATCTGGTAATGACATGAAGCTTGAACCTGTCGTCTCG
CTTTCGGACATTAAAGTGGATGAGAATGGATATGTGAAAATTTTAGAGACGGCTGTAGAACTTACCGGCGTGTATGATCT
ATTTAAAGCAGCCACGGGCAGAGATCCGGTATCAGGCGAAAAAGTCACAGGGAAAGACCGTGTTGTTGCCTCCATAAACT
CAGTACCATTTGCCAAAATAGCTAAGTTAGAAAAGTTAATAGATATTAATAAACTTATTAATAATGGGAAAAAGGCTAAG
AAGGCTTCGGAAGTTAAAAACGTTGCTAAGGATAAAGGGAAAATTGCGAATGATGTAAGTGGATCTGCTAATAAAATTAA
TTCTGATTTAATAAAAAAGTATGCTAGAGATATAGAACAACGCACAGGTAGAGAATTACCTAAAAATCAAATAGATAAAT
TAAAGGAAGCATTAAGAAATAAAGAATATAAAAAAATGTCACCAATAGAGACTGCAAAACACAGGACTAAATTTGATAAA
GTAAAAAATAAAGTTATAAAAGAATGGGAAGAAAACACTGGACAAAAATGGCCTGTTTATAAGGAAAATGTTGTATCTGA
AAAAACAGGTAAAATTATTAGAAAAAAAGGGGATAAGTATGATGCTCACCATATAATTGAAAATACTTTTGGCGGAGAAC
ATGAATGGTGGAATATGCATCCAGCAAAATTTCCTAACGAGCATCAAGCTGGGATTCATGGTACAGGCTCACCAGCAAAT
GAATTATTTAAAGGAGGCAAAAAAAAATGA
TTGAAAACATTAGATGTCCACGCTCTTCACGAGGGCATTCAGCATACGATTGAGAAACTGGACAAGCAAAAACAACAGCT
GGAGAAGCTGGAAAAAAGCGTTGAGCATCTGGCAGGCATGAAGGATGCGCTGAAAGGAAAAGGCGGAGATGCCATCCGGA
CCTTTTACGAGGAGTGCCACAAGCCTTTTCTCCTTTTCTTTGGCATATTTATCGACGAATACAAAAAAGTGCTGAAACAA
ACACAGCATGCGATTTCCTCTGTAGAATCTAACTCCCACGGCATGATCGCAGAGGCTTTTCTCTCACACGATGCGAGACA
TGGGGTCAAGCATGCACGAGAAGTGACAGAGCAGCTCACTGACGCAGTCAATCGCCAGACATCAGCCATAGATCACATCG
TCAGCCTGCCGACAGTCAATGATTCCTTTTTTCGGATGGAAACAGAACAGGCTGAGCGGCTGATTTCAGACACCCTGAAT
AAGCTCTTTCAATTTGACGGCCAGCAAACCCAAGCACTAGAAGCCGCAAAATCAGATTTTCAAACGATGAAAAAATACAT
TGATCAGCTCGAAACCATGTACACCGGCCCGAAAATTGAAATCACAGGCTACAAAAGCGGCTCCATCCTGAAATCACAGG
AAGAAGAAAACATCAACCAAATCTTCGGCGCGATTAACCCGCAAATGAAGCAGGCGGATGATTCACCGATGGAGATGATG
CTGAAGAAATTAGCCGAGAATGAAAAGTCTAAAGTGGATTCAGTTGTCAAAACGGGTGATTCTAAAAAGGTAAGTAAAAA
TATCATCGTTATCAATGGTAAAGTGTATAATACGAGTGAACATAGAGAACATATAAAAACTGATTTCTCAAATGCAGAGG
TTAAGCAAGTCGTTTATAATGATACACTTTACAATGTATACATATCTGGTAATGACATGAAGCTTGAACCTGTCGTCTCG
CTTTCGGACATTAAAGTGGATGAGAATGGATATGTGAAAATTTTAGAGACGGCTGTAGAACTTACCGGCGTGTATGATCT
ATTTAAAGCAGCCACGGGCAGAGATCCGGTATCAGGCGAAAAAGTCACAGGGAAAGACCGTGTTGTTGCCTCCATAAACT
CAGTACCATTTGCCAAAATAGCTAAGTTAGAAAAGTTAATAGATATTAATAAACTTATTAATAATGGGAAAAAGGCTAAG
AAGGCTTCGGAAGTTAAAAACGTTGCTAAGGATAAAGGGAAAATTGCGAATGATGTAAGTGGATCTGCTAATAAAATTAA
TTCTGATTTAATAAAAAAGTATGCTAGAGATATAGAACAACGCACAGGTAGAGAATTACCTAAAAATCAAATAGATAAAT
TAAAGGAAGCATTAAGAAATAAAGAATATAAAAAAATGTCACCAATAGAGACTGCAAAACACAGGACTAAATTTGATAAA
GTAAAAAATAAAGTTATAAAAGAATGGGAAGAAAACACTGGACAAAAATGGCCTGTTTATAAGGAAAATGTTGTATCTGA
AAAAACAGGTAAAATTATTAGAAAAAAAGGGGATAAGTATGATGCTCACCATATAATTGAAAATACTTTTGGCGGAGAAC
ATGAATGGTGGAATATGCATCCAGCAAAATTTCCTAACGAGCATCAAGCTGGGATTCATGGTACAGGCTCACCAGCAAAT
GAATTATTTAAAGGAGGCAAAAAAAAATGA
Antitoxin
Download Length: 148 a.a. Molecular weight: 21800.15 Da Isoelectric Point: 5.5500
>AT10057 WP_003244256.1 NZ_CP034484:c4032034-4031591 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEVGYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPD
IEIYDEFENDKLIFFEGSESALMSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE
MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEVGYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPD
IEIYDEFENDKLIFFEGSESALMSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE
Download Length: 444 bp
>AT10057 NZ_CP034484:c4032034-4031591 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
ATGAGTTATAATTTTATAAAATCAAACAAAGAAAATGATTTTTATCCAGTGAATCAAAGTGAGATTGAAGAGGTTGAAAA
AAATTTAAACTTAAAATTACCTAGTGAATTAGTGAATTTTTATTTAGAAGTTGGCTATGGGTTTATTAAAGGATCAGAGT
TTAATACTAATCGCATTTTGGATCCATATTCTGTAAGAGACTTTCGATTGAGGATAAATGACTTTGAATTTTATCCTGAC
ATAGAAATATATGATGAGTTTGAGAATGATAAATTAATATTTTTTGAAGGTAGTGAATCGGCATTAATGTCAATTGAATT
AAATGATAATAATAAAAATCCGATTTACTATTATGATATTCAAATTGCAACTTCTCTTACCGAGTTCTTAAGAAAAATAG
AAGAGAATGATCAGTATTATCTTGATTTATTAGATGATGAATGA
ATGAGTTATAATTTTATAAAATCAAACAAAGAAAATGATTTTTATCCAGTGAATCAAAGTGAGATTGAAGAGGTTGAAAA
AAATTTAAACTTAAAATTACCTAGTGAATTAGTGAATTTTTATTTAGAAGTTGGCTATGGGTTTATTAAAGGATCAGAGT
TTAATACTAATCGCATTTTGGATCCATATTCTGTAAGAGACTTTCGATTGAGGATAAATGACTTTGAATTTTATCCTGAC
ATAGAAATATATGATGAGTTTGAGAATGATAAATTAATATTTTTTGAAGGTAGTGAATCGGCATTAATGTCAATTGAATT
AAATGATAATAATAAAAATCCGATTTACTATTATGATATTCAAATTGCAACTTCTCTTACCGAGTTCTTAAGAAAAATAG
AAGAGAATGATCAGTATTATCTTGATTTATTAGATGATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| T6030 | Bacillus subtilis subsp. subtilis str. 168 |
100 |
100 |
1 |
Multiple sequence alignment
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT6030 | Bacillus subtilis subsp. subtilis str. 168 |
100 |
100 |
1 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A164URN3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A164URM8 |
References
(1) Kazuo Kobayashi (2021) Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms. PLoS Genetics 17(7):e1009682. [PubMed:34280190]