Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2875076..2875665 Replicon chromosome
Accession NZ_CP027862
Organism Actinomyces sp. Z16

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag C3B71_RS12040 Protein ID WP_108968340.1
Coordinates 2875384..2875665 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C3B71_RS12035 Protein ID WP_108968338.1
Coordinates 2875076..2875375 (-) Length 100 a.a.

Genomic Context

C3B71_RS12010C3B71_RS12030C3B71_RS12045C3B71_RS12050C3B71_RS12060C3B71_RS12065C3B71_RS12005C3B71_RS12020C3B71_RS12025C3B71_RS12035C3B71_RS12040C3B71_RS12055
Location: 2871426..2871659 (234 bp)
Type: Others
Protein ID: WP_108968332.1
Location: 2874613..2875050 (438 bp)
Type: Others
Protein ID: WP_108969895.1
Location: 2875815..2876030 (216 bp)
Type: Others
Protein ID: WP_108968342.1
Location: 2876027..2876311 (285 bp)
Type: Others
Protein ID: WP_108968344.1
Location: 2877476..2878792 (1317 bp)
Type: Others
Protein ID: WP_108968347.1
Location: 2878953..2879612 (660 bp)
Type: Others
Protein ID: WP_108968349.1
Location: 2870479..2871312 (834 bp)
Type: Others
Protein ID: WP_073328407.1
Location: 2871896..2872633 (738 bp)
Type: Others
Protein ID: WP_159097688.1
Location: 2872743..2873771 (1029 bp)
Type: Others
Protein ID: WP_199912507.1
Location: 2875076..2875375 (300 bp)
Type: Antitoxin
Protein ID: WP_108968338.1
Location: 2875384..2875665 (282 bp)
Type: Toxin
Protein ID: WP_108968340.1
Location: 2876321..2877406 (1086 bp)
Type: Others
Protein ID: WP_108969897.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C3B71_RS120052870479..2871312-834WP_073328407.1MerR family transcriptional regulator-
C3B71_RS120102871426..2871659+234WP_108968332.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C3B71_RS120202871896..2872633-738WP_159097688.1alpha/beta hydrolase-
C3B71_RS120252872743..2873771-1029WP_199912507.1NADP-dependent oxidoreductase-
C3B71_RS120302874613..2875050+438WP_108969895.1helix-turn-helix transcriptional regulator-
C3B71_RS120352875076..2875375-300WP_108968338.1HigA family addiction module antidote proteinAntitoxin
C3B71_RS120402875384..2875665-282WP_108968340.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C3B71_RS120452875815..2876030+216WP_108968342.1hypothetical protein-
C3B71_RS120502876027..2876311+285WP_108968344.1type II toxin-antitoxin system RelE/ParE family toxin-
C3B71_RS120552876321..2877406-1086WP_108969897.1redox-regulated ATPase YchF-
C3B71_RS120602877476..2878792+1317WP_108968347.1DNA recombination protein RmuC-
C3B71_RS120652878953..2879612+660WP_108968349.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(19-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10870.39 Da        Isoelectric Point: 9.9269

>T100388 WP_108968340.1 NZ_CP027862:c2875665-2875384 [Actinomyces sp. Z16]
VIRSLGDRDTECVWLREPARRIDPRIHRTANRKLRQLDAVVSLNSLRVPPGNHLEALKGDRRGQYSIRINDQWRICFVWT
AAGPENVIIEDYH

Download         Length: 282 bp

>T100388 NZ_CP027862:c2875665-2875384 [Actinomyces sp. Z16]
GTGATCAGGTCCCTCGGTGATCGGGATACGGAGTGCGTGTGGCTGCGTGAGCCGGCCCGGCGGATCGACCCACGGATTCA
TCGGACGGCAAACCGGAAACTGCGTCAGCTTGATGCCGTTGTGTCGCTCAACTCGCTTCGAGTCCCGCCCGGGAATCACC
TCGAAGCTTTGAAGGGTGATCGCAGAGGTCAGTACAGCATCCGGATCAATGACCAGTGGCGGATCTGTTTTGTGTGGACC
GCCGCCGGACCCGAGAACGTGATCATCGAGGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11068.80 Da        Isoelectric Point: 6.7251

>AT100388 WP_108968338.1 NZ_CP027862:c2875375-2875076 [Actinomyces sp. Z16]
MTDKLYAPIHPGEVLMEDFINAFGVTQHKLAVSIGVPPRRINEIVHGKRAITADTALRLGRYFGVEPQFWLNLQSRYELE
LAEGRIAAELDAIKPIQAA

Download         Length: 300 bp

>AT100388 NZ_CP027862:c2875375-2875076 [Actinomyces sp. Z16]
ATGACTGACAAGCTCTACGCGCCGATCCATCCGGGCGAGGTCCTGATGGAGGATTTCATCAATGCCTTCGGCGTTACGCA
GCACAAGCTCGCGGTGTCGATCGGTGTGCCTCCGCGTCGGATCAACGAGATCGTGCATGGCAAGCGGGCGATTACCGCGG
ACACGGCGCTGCGCCTGGGGCGTTACTTCGGCGTTGAGCCGCAGTTCTGGCTCAACCTGCAGTCGCGGTACGAGCTGGAA
CTGGCGGAGGGCCGCATCGCCGCTGAGCTCGACGCCATCAAGCCCATCCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References