Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2875076..2875665 Replicon chromosome
Accession NZ_CP027862
Organism Actinomyces sp. Z16

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag C3B71_RS12040 Protein ID WP_108968340.1
Coordinates 2875384..2875665 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C3B71_RS12035 Protein ID WP_108968338.1
Coordinates 2875076..2875375 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3B71_RS12005 2870479..2871312 - 834 WP_073328407.1 MerR family transcriptional regulator -
C3B71_RS12010 2871426..2871659 + 234 WP_108968332.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
C3B71_RS12020 2871896..2872633 - 738 WP_159097688.1 alpha/beta hydrolase -
C3B71_RS12025 2872743..2873771 - 1029 WP_199912507.1 NADP-dependent oxidoreductase -
C3B71_RS12030 2874613..2875050 + 438 WP_108969895.1 helix-turn-helix transcriptional regulator -
C3B71_RS12035 2875076..2875375 - 300 WP_108968338.1 HigA family addiction module antidote protein Antitoxin
C3B71_RS12040 2875384..2875665 - 282 WP_108968340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3B71_RS12045 2875815..2876030 + 216 WP_108968342.1 hypothetical protein -
C3B71_RS12050 2876027..2876311 + 285 WP_108968344.1 type II toxin-antitoxin system RelE/ParE family toxin -
C3B71_RS12055 2876321..2877406 - 1086 WP_108969897.1 redox-regulated ATPase YchF -
C3B71_RS12060 2877476..2878792 + 1317 WP_108968347.1 DNA recombination protein RmuC -
C3B71_RS12065 2878953..2879612 + 660 WP_108968349.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(19-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10870.39 Da        Isoelectric Point: 9.9269

>T100388 WP_108968340.1 NZ_CP027862:c2875665-2875384 [Actinomyces sp. Z16]
VIRSLGDRDTECVWLREPARRIDPRIHRTANRKLRQLDAVVSLNSLRVPPGNHLEALKGDRRGQYSIRINDQWRICFVWT
AAGPENVIIEDYH

Download         Length: 282 bp

>T100388 NZ_CP027862:c2875665-2875384 [Actinomyces sp. Z16]
GTGATCAGGTCCCTCGGTGATCGGGATACGGAGTGCGTGTGGCTGCGTGAGCCGGCCCGGCGGATCGACCCACGGATTCA
TCGGACGGCAAACCGGAAACTGCGTCAGCTTGATGCCGTTGTGTCGCTCAACTCGCTTCGAGTCCCGCCCGGGAATCACC
TCGAAGCTTTGAAGGGTGATCGCAGAGGTCAGTACAGCATCCGGATCAATGACCAGTGGCGGATCTGTTTTGTGTGGACC
GCCGCCGGACCCGAGAACGTGATCATCGAGGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11068.80 Da        Isoelectric Point: 6.7251

>AT100388 WP_108968338.1 NZ_CP027862:c2875375-2875076 [Actinomyces sp. Z16]
MTDKLYAPIHPGEVLMEDFINAFGVTQHKLAVSIGVPPRRINEIVHGKRAITADTALRLGRYFGVEPQFWLNLQSRYELE
LAEGRIAAELDAIKPIQAA

Download         Length: 300 bp

>AT100388 NZ_CP027862:c2875375-2875076 [Actinomyces sp. Z16]
ATGACTGACAAGCTCTACGCGCCGATCCATCCGGGCGAGGTCCTGATGGAGGATTTCATCAATGCCTTCGGCGTTACGCA
GCACAAGCTCGCGGTGTCGATCGGTGTGCCTCCGCGTCGGATCAACGAGATCGTGCATGGCAAGCGGGCGATTACCGCGG
ACACGGCGCTGCGCCTGGGGCGTTACTTCGGCGTTGAGCCGCAGTTCTGGCTCAACCTGCAGTCGCGGTACGAGCTGGAA
CTGGCGGAGGGCCGCATCGCCGCTGAGCTCGACGCCATCAAGCCCATCCAAGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References