Detailed information of TA system TA100364

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-Phd
• Location: 3409670..3410175
• Replicon: chromosome
• Accession: NZ_CP027806
• Organism: Candidatus Cyclonatronum proteinivorum strain Omega

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CYPRO_RS12960
• Protein ID: WP_114985018.1
• Coordinates: 3409670..3409936 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CYPRO_RS12965
• Protein ID: WP_114985803.1
• Coordinates: 3409933..3410175 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYPRO_RS12935	3405174..3405728	+	555	WP_114985013.1	hypothetical protein	-
CYPRO_RS12940	3405880..3406659	+	780	WP_114985014.1	electron transfer flavoprotein subunit beta/FixA family protein	-
CYPRO_RS12945	3406731..3407708	+	978	WP_114985015.1	electron transfer flavoprotein subunit alpha/FixB family protein	-
CYPRO_RS12950	3407718..3409043	+	1326	WP_114985016.1	FAD-dependent oxidoreductase	-
CYPRO_RS12955	3409040..3409342	+	303	WP_114985017.1	4Fe-4S dicluster domain-containing protein	-
CYPRO_RS12960	3409670..3409936	-	267	WP_114985018.1	Txe/YoeB family addiction module toxin	Toxin
CYPRO_RS12965	3409933..3410175	-	243	WP_114985803.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CYPRO_RS12970	3410486..3410896	-	411	WP_114985804.1	DinB family protein	-
CYPRO_RS12975	3411092..3414184	-	3093	WP_114985019.1	SMC family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10320.97 Da
• Isoelectric Point: 9.8752

>T100364 WP_114985018.1 NZ_CP027806:c3409936-3409670 [Candidatus Cyclonatronum proteinivorum]
VSKYKLVYTKQAKKDAKKAASSGLKPKIEDLLDIIKENPSQDYPPYEKLVGNLEGAYSRRINIQHRLVYQVLEEEKIVKV
IRMWTHYD

Nucleotide

• Length: 267 bp

>T100364 NZ_CP027806:c3409936-3409670 [Candidatus Cyclonatronum proteinivorum]
GTGAGTAAATACAAACTCGTTTACACAAAACAAGCAAAAAAAGATGCTAAAAAAGCGGCTTCCTCGGGGTTAAAGCCTAA
AATTGAGGATTTACTGGATATTATAAAGGAGAATCCCTCTCAAGATTACCCTCCGTATGAAAAACTTGTCGGTAATTTGG
AGGGAGCTTATTCCAGGCGCATCAACATCCAGCACCGCTTGGTTTACCAGGTCCTTGAGGAAGAGAAGATTGTAAAGGTG
ATTCGTATGTGGACGCATTACGACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9211.25 Da
• Isoelectric Point: 4.1169

>AT100364 WP_114985803.1 NZ_CP027806:c3410175-3409933 [Candidatus Cyclonatronum proteinivorum]
MKTLTATQARKEIYRLLDEASETHEPIQITGKRTNAVLISEDDWRSIQETLYLSSISGMQESIIEGLRTPVEETDEELDW

Nucleotide

• Length: 243 bp

>AT100364 NZ_CP027806:c3410175-3409933 [Candidatus Cyclonatronum proteinivorum]
ATGAAGACATTAACTGCCACACAAGCCCGGAAAGAGATTTACCGGCTATTAGATGAGGCTTCTGAAACCCACGAGCCAAT
TCAAATAACCGGCAAGAGAACCAATGCGGTACTCATAAGCGAGGATGACTGGCGATCCATTCAGGAAACACTCTATCTGT
CTTCTATTTCAGGAATGCAGGAGTCTATTATTGAAGGGCTACGAACTCCTGTCGAAGAAACCGATGAAGAGCTTGACTGG
TGA