Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2760735..2761363 Replicon chromosome
Accession NZ_CP027792
Organism Pulveribacter suum strain SC2-7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C7H73_RS12610 Protein ID WP_106846969.1
Coordinates 2761082..2761363 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C7H73_RS12605 Protein ID WP_106846968.1
Coordinates 2760735..2761034 (-) Length 100 a.a.

Genomic Context

C7H73_RS12590C7H73_RS12595C7H73_RS12600C7H73_RS12615C7H73_RS12625C7H73_RS12630C7H73_RS12605C7H73_RS12610C7H73_RS12620C7H73_RS12635
Location: 2756184..2757380 (1197 bp)
Type: Others
Protein ID: WP_106846966.1
Location: 2757377..2757940 (564 bp)
Type: Others
Protein ID: WP_106847665.1
Location: 2757952..2760618 (2667 bp)
Type: Others
Protein ID: WP_106846967.1
Location: 2761444..2761860 (417 bp)
Type: Others
Protein ID: WP_106847666.1
Location: 2762869..2763924 (1056 bp)
Type: Others
Protein ID: WP_106846971.1
Location: 2763944..2765083 (1140 bp)
Type: Others
Protein ID: WP_106846972.1
Location: 2760735..2761034 (300 bp)
Type: Antitoxin
Protein ID: WP_106846968.1
Location: 2761082..2761363 (282 bp)
Type: Toxin
Protein ID: WP_106846969.1
Location: 2761813..2762637 (825 bp)
Type: Others
Protein ID: WP_170104813.1
Location: 2765338..2765766 (429 bp)
Type: Others
Protein ID: WP_106846973.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C7H73_RS125902756184..2757380+1197WP_106846966.1AAA family ATPase-
C7H73_RS125952757377..2757940+564WP_106847665.1DUF4276 family protein-
C7H73_RS126002757952..2760618+2667WP_106846967.1ABC transporter permease-
C7H73_RS126052760735..2761034-300WP_106846968.1HigA family addiction module antidote proteinAntitoxin
C7H73_RS126102761082..2761363-282WP_106846969.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C7H73_RS126152761444..2761860+417WP_106847666.1PT domain-containing protein-
C7H73_RS126202761813..2762637-825WP_170104813.1GIY-YIG nuclease family protein-
C7H73_RS126252762869..2763924+1056WP_106846971.1PLP-dependent cysteine synthase family protein-
C7H73_RS126302763944..2765083+1140WP_106846972.1carotenoid 1,2-hydratase-
C7H73_RS126352765338..2765766-429WP_106846973.1Hsp20/alpha crystallin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10940.60 Da        Isoelectric Point: 7.3542

>T100330 WP_106846969.1 NZ_CP027792:c2761363-2761082 [Pulveribacter suum]
MAIQCFKCDDTESLFRLERVRRWVNIEVAALRKLRLLHAAHVLHDLRIPPGNRLEALKGDREGQHSIRINDQWRVCFVWT
PEGPADVEIVDYH

Download         Length: 282 bp

>T100330 NZ_CP027792:c2761363-2761082 [Pulveribacter suum]
ATGGCCATCCAGTGCTTCAAATGCGATGACACGGAGTCACTGTTCAGACTGGAGCGCGTGCGTCGCTGGGTCAACATCGA
AGTTGCGGCACTGCGCAAATTGCGCCTTTTGCATGCCGCCCATGTTCTGCACGACTTGCGCATTCCCCCAGGCAATCGAC
TGGAAGCGCTCAAGGGCGATCGCGAGGGCCAGCACAGCATTCGCATCAATGACCAATGGCGCGTGTGTTTTGTATGGACC
CCTGAAGGGCCAGCGGACGTCGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10838.48 Da        Isoelectric Point: 4.2702

>AT100330 WP_106846968.1 NZ_CP027792:c2761034-2760735 [Pulveribacter suum]
MTEQLTLPTPGEILATEFLEPLGITQYRLAQAILVPQSRIAAIIKDGRVITADTALRLARFFGTSVEFWMSLQGQYDADT
ARLKLGEELEAIEPFAAAG

Download         Length: 300 bp

>AT100330 NZ_CP027792:c2761034-2760735 [Pulveribacter suum]
ATGACCGAACAGCTGACGCTTCCGACCCCCGGCGAGATCCTCGCCACTGAGTTCCTGGAGCCTCTGGGCATCACACAGTA
CCGGCTGGCCCAGGCCATCCTTGTACCGCAGAGCCGCATCGCCGCCATCATCAAGGATGGCCGGGTGATCACGGCAGATA
CGGCGCTGCGGCTGGCGCGATTCTTCGGCACGTCGGTGGAGTTCTGGATGAGCCTGCAGGGCCAGTACGACGCCGACACC
GCCAGGCTCAAACTGGGCGAAGAGCTGGAAGCCATCGAGCCGTTCGCAGCGGCTGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References