Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2760735..2761363 Replicon chromosome
Accession NZ_CP027792
Organism Pulveribacter suum strain SC2-7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C7H73_RS12610 Protein ID WP_106846969.1
Coordinates 2761082..2761363 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C7H73_RS12605 Protein ID WP_106846968.1
Coordinates 2760735..2761034 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7H73_RS12590 2756184..2757380 + 1197 WP_106846966.1 AAA family ATPase -
C7H73_RS12595 2757377..2757940 + 564 WP_106847665.1 DUF4276 family protein -
C7H73_RS12600 2757952..2760618 + 2667 WP_106846967.1 ABC transporter permease -
C7H73_RS12605 2760735..2761034 - 300 WP_106846968.1 HigA family addiction module antidote protein Antitoxin
C7H73_RS12610 2761082..2761363 - 282 WP_106846969.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7H73_RS12615 2761444..2761860 + 417 WP_106847666.1 PT domain-containing protein -
C7H73_RS12620 2761813..2762637 - 825 WP_170104813.1 GIY-YIG nuclease family protein -
C7H73_RS12625 2762869..2763924 + 1056 WP_106846971.1 PLP-dependent cysteine synthase family protein -
C7H73_RS12630 2763944..2765083 + 1140 WP_106846972.1 carotenoid 1,2-hydratase -
C7H73_RS12635 2765338..2765766 - 429 WP_106846973.1 Hsp20/alpha crystallin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10940.60 Da        Isoelectric Point: 7.3542

>T100330 WP_106846969.1 NZ_CP027792:c2761363-2761082 [Pulveribacter suum]
MAIQCFKCDDTESLFRLERVRRWVNIEVAALRKLRLLHAAHVLHDLRIPPGNRLEALKGDREGQHSIRINDQWRVCFVWT
PEGPADVEIVDYH

Download         Length: 282 bp

>T100330 NZ_CP027792:c2761363-2761082 [Pulveribacter suum]
ATGGCCATCCAGTGCTTCAAATGCGATGACACGGAGTCACTGTTCAGACTGGAGCGCGTGCGTCGCTGGGTCAACATCGA
AGTTGCGGCACTGCGCAAATTGCGCCTTTTGCATGCCGCCCATGTTCTGCACGACTTGCGCATTCCCCCAGGCAATCGAC
TGGAAGCGCTCAAGGGCGATCGCGAGGGCCAGCACAGCATTCGCATCAATGACCAATGGCGCGTGTGTTTTGTATGGACC
CCTGAAGGGCCAGCGGACGTCGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10838.48 Da        Isoelectric Point: 4.2702

>AT100330 WP_106846968.1 NZ_CP027792:c2761034-2760735 [Pulveribacter suum]
MTEQLTLPTPGEILATEFLEPLGITQYRLAQAILVPQSRIAAIIKDGRVITADTALRLARFFGTSVEFWMSLQGQYDADT
ARLKLGEELEAIEPFAAAG

Download         Length: 300 bp

>AT100330 NZ_CP027792:c2761034-2760735 [Pulveribacter suum]
ATGACCGAACAGCTGACGCTTCCGACCCCCGGCGAGATCCTCGCCACTGAGTTCCTGGAGCCTCTGGGCATCACACAGTA
CCGGCTGGCCCAGGCCATCCTTGTACCGCAGAGCCGCATCGCCGCCATCATCAAGGATGGCCGGGTGATCACGGCAGATA
CGGCGCTGCGGCTGGCGCGATTCTTCGGCACGTCGGTGGAGTTCTGGATGAGCCTGCAGGGCCAGTACGACGCCGACACC
GCCAGGCTCAAACTGGGCGAAGAGCTGGAAGCCATCGAGCCGTTCGCAGCGGCTGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References