Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2741076..2741599 Replicon chromosome
Accession NZ_CP027788
Organism Staphylococcus aureus strain CMRSA-6

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag C7M55_RS14590 Protein ID WP_000074048.1
Coordinates 2741076..2741342 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag C7M55_RS14595 Protein ID WP_000587616.1
Coordinates 2741342..2741599 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M55_RS14570 2736383..2737570 - 1188 WP_000026194.1 MFS transporter -
C7M55_RS14575 2737966..2738742 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
C7M55_RS14580 2738735..2739397 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
C7M55_RS14585 2739645..2740721 - 1077 WP_001076671.1 M42 family metallopeptidase -
C7M55_RS14590 2741076..2741342 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
C7M55_RS14595 2741342..2741599 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C7M55_RS14605 2741958..2742413 + 456 WP_000732080.1 DUF1307 domain-containing protein -
C7M55_RS14610 2742581..2744158 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
C7M55_RS14615 2744353..2745102 + 750 WP_000072442.1 hypothetical protein -
C7M55_RS14620 2745326..2746519 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T100325 WP_000074048.1 NZ_CP027788:c2741342-2741076 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T100325 NZ_CP027788:c2741342-2741076 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT100325 WP_000587616.1 NZ_CP027788:c2741599-2741342 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT100325 NZ_CP027788:c2741599-2741342 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References