100323

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2709576..2709760 Replicon chromosome
Accession NZ_CP027788
Organism Staphylococcus aureus strain CMRSA-6

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag C7M55_RS14430 Protein ID WP_000482650.1
Coordinates 2709653..2709760 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2709576..2709636 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M55_RS14405 2705106..2705273 - 168 WP_001790576.1 hypothetical protein -
C7M55_RS14415 2705504..2707237 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
C7M55_RS14420 2707262..2709025 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2709576..2709636 + 61 - - Antitoxin
C7M55_RS14430 2709653..2709760 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
C7M55_RS14435 2709894..2710280 - 387 WP_000779358.1 flippase GtxA -
C7M55_RS14440 2710548..2711690 + 1143 WP_001176863.1 glycerate kinase -
C7M55_RS14445 2711750..2712409 + 660 WP_000831298.1 membrane protein -
C7M55_RS14450 2712591..2713802 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
C7M55_RS14455 2713925..2714398 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-124)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T100323 WP_000482650.1 NZ_CP027788:c2709760-2709653 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T100323 NZ_CP027788:c2709760-2709653 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT100323 NZ_CP027788:2709576-2709636 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References