Detailed information of TA system TA100321

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2419213..2419430
• Replicon: chromosome
• Accession: NZ_CP027788
• Organism: Staphylococcus aureus strain CMRSA-6

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: C7M55_RS12845
• Protein ID: WP_001802298.1
• Coordinates: 2419326..2419430 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2419213..2419268 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7M55_RS12825	2415350..2416015	-	666	WP_001024094.1	SDR family oxidoreductase	-
C7M55_RS12830	2416167..2416487	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
C7M55_RS12835	2416489..2417469	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
C7M55_RS12840	2417735..2418826	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2419213..2419268	+	56	-	-	Antitoxin
C7M55_RS12845	2419326..2419430	-	105	WP_001802298.1	hypothetical protein	Toxin
C7M55_RS16115	2419591..2420074	-	484	Protein_2385	recombinase family protein	-
C7M55_RS12855	2420117..2421253	-	1137	WP_000115564.1	SAP domain-containing protein	-
C7M55_RS12860	2421542..2421634	+	93	WP_001790138.1	hypothetical protein	-
C7M55_RS12865	2422339..2423196	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
C7M55_RS12870	2423264..2424046	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T100321 WP_001802298.1 NZ_CP027788:c2419430-2419326 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T100321 NZ_CP027788:c2419430-2419326 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT100321 NZ_CP027788:2419213-2419268 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin