100318

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2419151..2419430 Replicon chromosome
Accession NZ_CP027788
Organism Staphylococcus aureus strain CMRSA-6

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag C7M55_RS12845 Protein ID WP_001802298.1
Coordinates 2419326..2419430 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2419151..2419330 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M55_RS12825 2415350..2416015 - 666 WP_001024094.1 SDR family oxidoreductase -
C7M55_RS12830 2416167..2416487 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
C7M55_RS12835 2416489..2417469 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
C7M55_RS12840 2417735..2418826 + 1092 WP_000495671.1 lytic regulatory protein -
- 2419151..2419330 + 180 - - Antitoxin
C7M55_RS12845 2419326..2419430 - 105 WP_001802298.1 hypothetical protein Toxin
C7M55_RS16115 2419591..2420074 - 484 Protein_2385 recombinase family protein -
C7M55_RS12855 2420117..2421253 - 1137 WP_000115564.1 SAP domain-containing protein -
C7M55_RS12860 2421542..2421634 + 93 WP_001790138.1 hypothetical protein -
C7M55_RS12865 2422339..2423196 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
C7M55_RS12870 2423264..2424046 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T100318 WP_001802298.1 NZ_CP027788:c2419430-2419326 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T100318 NZ_CP027788:c2419430-2419326 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 180 bp

>AT100318 NZ_CP027788:2419151-2419330 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References