Detailed information of TA system TA100311

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2114915..2115214
• Replicon: chromosome
• Accession: NZ_CP027788
• Organism: Staphylococcus aureus strain CMRSA-6

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: C7M55_RS11065
• Protein ID: WP_072482930.1
• Coordinates: 2115038..2115214 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2114915..2114970 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7M55_RS11010	2110473..2110652	+	180	WP_000669789.1	hypothetical protein	-
C7M55_RS11020	2110963..2111223	+	261	WP_001791826.1	hypothetical protein	-
C7M55_RS11025	2111276..2111626	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
C7M55_RS11030	2112136..2112471	-	336	Protein_2033	SH3 domain-containing protein	-
C7M55_RS11045	2113123..2113614	-	492	WP_000920041.1	staphylokinase	-
C7M55_RS11050	2113805..2114560	-	756	WP_000861038.1	CHAP domain-containing protein	-
C7M55_RS11055	2114572..2114826	-	255	WP_000611512.1	phage holin	-
C7M55_RS11060	2114878..2114985	+	108	Protein_2037	hypothetical protein	-
-	2114907..2115046	+	140	NuclAT_0	-	-
-	2114907..2115046	+	140	NuclAT_0	-	-
-	2114907..2115046	+	140	NuclAT_0	-	-
-	2114907..2115046	+	140	NuclAT_0	-	-
-	2114915..2114970	+	56	-	-	Antitoxin
C7M55_RS11065	2115038..2115214	-	177	WP_072482930.1	putative holin-like toxin	Toxin
C7M55_RS11070	2115323..2116096	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
C7M55_RS11075	2116469..2116843	-	375	WP_000340977.1	hypothetical protein	-
C7M55_RS11080	2116899..2117186	-	288	WP_001262621.1	hypothetical protein	-
C7M55_RS11085	2117232..2117384	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2111276..2168801	57525

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T100311 WP_072482930.1 NZ_CP027788:c2115214-2115038 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T100311 NZ_CP027788:c2115214-2115038 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT100311 NZ_CP027788:2114915-2114970 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin