Detailed information of TA system TA100308

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1954622..1954804
• Replicon: chromosome
• Accession: NZ_CP027788
• Organism: Staphylococcus aureus strain CMRSA-6

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: C7M55_RS09985
• Protein ID: WP_001801861.1
• Coordinates: 1954622..1954717 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1954745..1954804 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7M55_RS09935	1950282..1950908	+	627	WP_000669046.1	hypothetical protein	-
C7M55_RS09940	1950949..1951293	+	345	WP_000627551.1	DUF3969 family protein	-
C7M55_RS09945	1951391..1951942	+	552	WP_000414205.1	hypothetical protein	-
C7M55_RS09950	1952160..1952801	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
C7M55_RS09955	1952915..1953100	-	186	WP_000809857.1	hypothetical protein	-
C7M55_RS09960	1953102..1953278	-	177	WP_000375476.1	hypothetical protein	-
C7M55_RS09965	1953289..1953672	-	384	WP_000070811.1	hypothetical protein	-
C7M55_RS09975	1954276..1954419	-	144	WP_001549059.1	transposase	-
C7M55_RS09985	1954622..1954717	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1954745..1954804	-	60	-	-	Antitoxin
C7M55_RS09990	1954840..1954941	+	102	WP_001791893.1	hypothetical protein	-
C7M55_RS09995	1954919..1955095	-	177	Protein_1880	transposase	-
C7M55_RS10000	1955289..1955666	-	378	WP_001037045.1	DUF1433 domain-containing protein	-
C7M55_RS10005	1956187..1957455	-	1269	Protein_1882	ATP-binding protein	-
C7M55_RS10015	1957507..1958678	-	1172	Protein_1883	IS256-like element IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1928584..1987973	59389

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T100308 WP_001801861.1 NZ_CP027788:1954622-1954717 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T100308 NZ_CP027788:1954622-1954717 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT100308 NZ_CP027788:c1954804-1954745 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin