Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2393829..2394492 Replicon chromosome
Accession NZ_CP027761
Organism Pseudomonas sp. R11-23-07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4J84_RS11015 Protein ID WP_124435322.1
Coordinates 2393829..2394194 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4J84_RS11020 Protein ID WP_124419815.1
Coordinates 2394187..2394492 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J84_RS10990 2388895..2389449 + 555 WP_124435317.1 histidine phosphatase family protein -
C4J84_RS10995 2389495..2390250 + 756 WP_124435318.1 precorrin-6A synthase (deacetylating) -
C4J84_RS11000 2390263..2390982 + 720 WP_124435319.1 alpha/beta fold hydrolase -
C4J84_RS11005 2391113..2391667 - 555 WP_124435320.1 hypothetical protein -
C4J84_RS11010 2391740..2393548 - 1809 WP_124435321.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
C4J84_RS11015 2393829..2394194 + 366 WP_124435322.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4J84_RS11020 2394187..2394492 + 306 WP_124419815.1 XRE family transcriptional regulator Antitoxin
C4J84_RS11025 2394587..2396143 + 1557 WP_124435323.1 DUF726 domain-containing protein -
C4J84_RS11030 2396182..2397501 + 1320 WP_124370452.1 Nramp family divalent metal transporter -
C4J84_RS11035 2397503..2398435 - 933 Protein_2125 LysR family transcriptional regulator -
C4J84_RS11040 2398551..2399039 + 489 WP_124362518.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(17-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13761.53 Da        Isoelectric Point: 7.1286

>T100254 WP_124435322.1 NZ_CP027761:2393829-2394194 [Pseudomonas sp. R11-23-07]
MVWDIEYTDEFGEWWGNLGENEQASVAASVDLLGLLGPGLGFPHSSDIRGSRHGNLRELRIQHAGRPYRVLYAFDPRRCA
VLLIGGDKTAQHRWYDVHVPVAEKLYDIHLKTLRKEGRTHG

Download         Length: 366 bp

>T100254 NZ_CP027761:2393829-2394194 [Pseudomonas sp. R11-23-07]
ATGGTATGGGACATTGAATACACGGATGAATTCGGCGAGTGGTGGGGCAACTTGGGTGAGAATGAGCAAGCTTCGGTTGC
TGCCAGCGTGGATCTGCTGGGCCTGCTCGGCCCGGGGCTTGGTTTTCCCCACAGCAGCGATATCAGAGGCTCTCGCCACG
GTAATCTGCGCGAACTGCGTATACAGCATGCAGGTCGTCCATATCGGGTGCTGTATGCCTTTGATCCCCGGCGCTGCGCA
GTCCTGCTGATAGGTGGCGATAAAACCGCACAGCATCGTTGGTACGACGTGCACGTACCGGTGGCGGAAAAGCTGTATGA
CATCCATTTGAAAACATTGCGCAAAGAGGGCCGTACCCATGGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11595.37 Da        Isoelectric Point: 9.6226

>AT100254 WP_124419815.1 NZ_CP027761:2394187-2394492 [Pseudomonas sp. R11-23-07]
MAKKFADLKARMTPESRADAEQLFQQHLKEMPLHELRKAQQLSQESLAKALNINQAAVSKMERRTDMYISTLRDYIRAMG
GELEIIATFPDGQVKIDNFAR

Download         Length: 306 bp

>AT100254 NZ_CP027761:2394187-2394492 [Pseudomonas sp. R11-23-07]
ATGGCTAAAAAATTCGCTGATCTCAAGGCGCGCATGACCCCCGAGTCGCGTGCCGATGCCGAGCAGCTTTTTCAACAGCA
TCTGAAAGAGATGCCCCTGCATGAGCTGCGCAAGGCGCAGCAACTGAGCCAGGAAAGCCTGGCCAAGGCGTTGAATATCA
ATCAGGCGGCGGTCTCGAAAATGGAGCGTCGCACCGATATGTACATCAGCACATTGCGCGACTACATACGTGCGATGGGG
GGAGAGCTGGAAATTATCGCGACGTTTCCCGATGGCCAGGTAAAAATCGACAACTTCGCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References