Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2482553..2483216 Replicon chromosome
Accession NZ_CP027759
Organism Pseudomonas sp. R2-7-07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4J86_RS11400 Protein ID WP_124362513.1
Coordinates 2482553..2482918 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4J86_RS11405 Protein ID WP_124362514.1
Coordinates 2482911..2483216 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J86_RS11380 2477689..2478444 + 756 WP_124370447.1 precorrin-6A synthase (deacetylating) -
C4J86_RS11385 2478457..2479164 + 708 WP_124370448.1 alpha/beta fold hydrolase -
C4J86_RS11390 2479837..2480391 - 555 WP_124370449.1 hypothetical protein -
C4J86_RS11395 2480464..2482272 - 1809 WP_124370450.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
C4J86_RS11400 2482553..2482918 + 366 WP_124362513.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4J86_RS11405 2482911..2483216 + 306 WP_124362514.1 XRE family transcriptional regulator Antitoxin
C4J86_RS11410 2483311..2484867 + 1557 WP_124370451.1 DUF726 domain-containing protein -
C4J86_RS11415 2484906..2486225 + 1320 WP_124370452.1 Nramp family divalent metal transporter -
C4J86_RS11420 2486227..2487159 - 933 WP_124370453.1 LysR family transcriptional regulator -
C4J86_RS11425 2487275..2487763 + 489 WP_124362518.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13720.56 Da        Isoelectric Point: 7.1284

>T100237 WP_124362513.1 NZ_CP027759:2482553-2482918 [Pseudomonas sp. R2-7-07]
MVWDIEYTDEFGEWWGNLGEKEQSSVAASVDLLGLLGPGLGFPHSSDIKGSRHGNLRELRIQHAGRPYRVLYAFDPRRCA
VLLIGGDKTAQHRWYDVHVPVAEKLYDIHLKTLRKEGLTHG

Download         Length: 366 bp

>T100237 NZ_CP027759:2482553-2482918 [Pseudomonas sp. R2-7-07]
ATGGTATGGGACATTGAATACACGGATGAATTCGGCGAGTGGTGGGGCAACTTGGGTGAGAAGGAGCAATCTTCGGTCGC
TGCCAGCGTGGATCTGCTGGGCCTGCTCGGCCCGGGGCTTGGCTTTCCCCACAGCAGCGATATCAAGGGCTCTCGCCACG
GCAATCTGCGCGAACTGCGTATACAGCACGCAGGTCGTCCCTATCGGGTGCTGTATGCCTTTGATCCCCGGCGCTGCGCA
GTCCTGCTGATAGGTGGCGATAAAACCGCACAGCATCGTTGGTACGACGTGCACGTACCGGTGGCGGAAAAGCTGTATGA
CATCCATTTGAAAACATTGCGCAAAGAGGGCCTTACCCATGGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11623.39 Da        Isoelectric Point: 9.6547

>AT100237 WP_124362514.1 NZ_CP027759:2482911-2483216 [Pseudomonas sp. R2-7-07]
MAKKFADLKARMTPESRADAEQLFQQHLREMPLHELRKAQQLSQESLAKALNINQAAVSKMERRTDMYISTLRDYIRAMG
GELEIIATFPDGQVKIDNFAR

Download         Length: 306 bp

>AT100237 NZ_CP027759:2482911-2483216 [Pseudomonas sp. R2-7-07]
ATGGCTAAAAAATTCGCTGATCTCAAGGCGCGCATGACTCCCGAGTCGCGTGCCGATGCCGAGCAGCTTTTTCAACAGCA
TCTGAGAGAGATGCCCCTGCATGAGCTGCGCAAGGCGCAGCAACTGAGCCAGGAAAGCCTGGCCAAGGCGTTGAATATCA
ATCAGGCGGCGGTCTCGAAAATGGAGCGTCGCACCGATATGTACATCAGCACATTGCGCGACTACATACGTGCGATGGGG
GGAGAGCTGGAAATTATCGCGACGTTTCCCGATGGCCAGGTAAAAATCGACAACTTCGCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References