100234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1446719..1447326 Replicon chromosome
Accession NZ_CP027759
Organism Pseudomonas sp. R2-7-07

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4J86_RS06455 Protein ID WP_124369842.1
Coordinates 1447012..1447326 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4J86_RS06450 Protein ID WP_124369841.1
Coordinates 1446719..1447012 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J86_RS06415 1441821..1442516 - 696 WP_124369836.1 tRNA (N6-threonylcarbamoyladenosine(37)-N6)-methyltransferase TrmO -
C4J86_RS06420 1442520..1442981 - 462 WP_124369837.1 DUF1456 family protein -
C4J86_RS06425 1443052..1443762 - 711 WP_124369838.1 rRNA pseudouridine synthase -
C4J86_RS06430 1443872..1444342 - 471 WP_124369839.1 GNAT family N-acetyltransferase -
C4J86_RS06435 1444443..1445771 - 1329 WP_177412771.1 30S ribosomal protein S12 methylthiotransferase RimO -
C4J86_RS06440 1446060..1446350 + 291 WP_124369840.1 hypothetical protein -
C4J86_RS06445 1446323..1446709 + 387 Protein_1243 hypothetical protein -
C4J86_RS06450 1446719..1447012 - 294 WP_124369841.1 helix-turn-helix domain-containing protein Antitoxin
C4J86_RS06455 1447012..1447326 - 315 WP_124369842.1 hypothetical protein Toxin
C4J86_RS06460 1448097..1449998 + 1902 WP_124361561.1 potassium transporter Kup -
C4J86_RS06465 1450165..1451271 + 1107 WP_124366074.1 NADH:flavin oxidoreductase/NADH oxidase -
C4J86_RS06470 1451493..1451678 + 186 WP_124369843.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11787.48 Da        Isoelectric Point: 8.3275

>T100234 WP_124369842.1 NZ_CP027759:c1447326-1447012 [Pseudomonas sp. R2-7-07]
VIFIESPIFTEDLGELLSDESYREFQEYLAENPTAGDVIQSTNGLRKVRWSANGKGKSGGVRVIYFYLSAAYQIRLILIY
RKGIKDDLSPAEKKVLAELNKGWK

Download         Length: 315 bp

>T100234 NZ_CP027759:c1447326-1447012 [Pseudomonas sp. R2-7-07]
GTGATATTCATTGAGTCCCCCATCTTCACGGAAGATCTTGGCGAGCTTCTGAGCGATGAAAGCTACCGCGAATTTCAGGA
GTACCTAGCCGAAAACCCAACGGCTGGTGATGTGATCCAAAGCACCAACGGACTGAGGAAGGTCCGCTGGAGCGCGAACG
GGAAAGGTAAGAGCGGTGGGGTTCGGGTGATCTATTTCTACCTATCGGCGGCTTACCAGATCAGGCTGATCCTGATCTAC
CGTAAGGGGATAAAAGACGATCTATCCCCAGCGGAAAAGAAAGTACTGGCAGAGTTAAACAAAGGGTGGAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11001.59 Da        Isoelectric Point: 10.1711

>AT100234 WP_124369841.1 NZ_CP027759:c1447012-1446719 [Pseudomonas sp. R2-7-07]
MEKNLFNRLVESMTQMDEIDRGERPPSREFHVDAVKVKMIRKATGLSQARFAKAIDVAVGTLQNWEQGRREPEGPARALL
RAIHNDPGHVLAALEQR

Download         Length: 294 bp

>AT100234 NZ_CP027759:c1447012-1446719 [Pseudomonas sp. R2-7-07]
ATGGAAAAGAATCTGTTCAACCGCCTGGTCGAAAGCATGACCCAGATGGACGAGATTGACCGTGGCGAACGCCCGCCGTC
CCGTGAGTTCCATGTGGATGCGGTGAAGGTCAAAATGATCCGCAAGGCCACAGGACTTTCCCAGGCACGTTTTGCCAAAG
CGATTGATGTCGCGGTGGGAACGCTCCAAAACTGGGAGCAAGGTCGGCGGGAGCCAGAAGGCCCCGCACGGGCACTCCTG
CGCGCCATACACAATGATCCTGGGCACGTATTAGCGGCTCTTGAGCAACGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References