100216

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 3931906..3932560 Replicon chromosome
Accession NZ_CP027756
Organism Pseudomonas synxantha strain R6-28-08

Toxin (Protein)


Gene name higB Uniprot ID A0A0R2YXS2
Locus tag C4K01_RS18145 Protein ID WP_057024311.1
Coordinates 3931906..3932256 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0W0N117
Locus tag C4K01_RS18150 Protein ID WP_014718915.1
Coordinates 3932246..3932560 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K01_RS18135 3928665..3930197 + 1533 WP_057024312.1 NADH-quinone oxidoreductase subunit M -
C4K01_RS18140 3930205..3931668 + 1464 WP_003192122.1 NADH-quinone oxidoreductase subunit NuoN -
C4K01_RS18145 3931906..3932256 + 351 WP_057024311.1 hypothetical protein Toxin
C4K01_RS18150 3932246..3932560 + 315 WP_014718915.1 XRE family transcriptional regulator Antitoxin
C4K01_RS18155 3932621..3933373 - 753 WP_057024310.1 outer membrane beta-barrel protein -
C4K01_RS18160 3933499..3934332 - 834 WP_057024309.1 arylamine N-acetyltransferase -
C4K01_RS18165 3934451..3934687 + 237 WP_005789137.1 hypothetical protein -
C4K01_RS18170 3934718..3934924 - 207 WP_046068647.1 hypothetical protein -
C4K01_RS18175 3934937..3935116 - 180 WP_046068648.1 hypothetical protein -
C4K01_RS18180 3935231..3935752 + 522 WP_057024308.1 DUF3087 domain-containing protein -
C4K01_RS18185 3935760..3936890 - 1131 WP_057024307.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13758.68 Da        Isoelectric Point: 9.7334

>T100216 WP_057024311.1 NZ_CP027756:3931906-3932256 [Pseudomonas synxantha]
MDALFIELPAFERHRKDYLSDELFQGFQQELMKTPEAGDVIEGTGGLRKVRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQSDLTPHHKKALKHMLDREIKARTHHET

Download         Length: 351 bp

>T100216 NZ_CP027756:3931906-3932256 [Pseudomonas synxantha]
ATGGATGCTCTATTTATCGAACTGCCGGCATTCGAGCGGCATCGCAAGGACTATCTCAGTGACGAGCTTTTCCAGGGTTT
TCAACAGGAGTTAATGAAAACCCCCGAAGCAGGAGATGTGATCGAAGGAACGGGCGGGTTGAGAAAGGTTCGCTTCGTTG
ATGAACGGCGAAACAAAGGCAAGCGTGGTGGCCTGCGAGTCATTTACTACTGGTGGTCAGGCGGCACGCAATTCTGGTTA
TTCACCTTGTACGGCAAGCACGAACAGAGCGACCTGACACCCCACCACAAGAAAGCTCTTAAACACATGCTGGACAGGGA
AATCAAAGCGAGAACACATCATGAAACGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11755.58 Da        Isoelectric Point: 10.6525

>AT100216 WP_014718915.1 NZ_CP027756:3932246-3932560 [Pseudomonas synxantha]
MKRDIFSELVEGFDALADERQGKITLRNHKVHLNKLAPLTADEVIAVRQQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQAVTLIRLVARFPETVAQLAALG

Download         Length: 315 bp

>AT100216 NZ_CP027756:3932246-3932560 [Pseudomonas synxantha]
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGCTTCGACGCCCTGGCCGATGAGCGCCAGGGTAAAATCACCCTGCG
CAACCACAAGGTCCACCTCAACAAGCTGGCGCCGCTCACCGCTGATGAGGTGATCGCCGTGCGCCAGCAACTCAACCTTT
CCCGGTCGGTATTCGCCATGTACCTGCGTACCAACACCCGCACCCTGGAGAACTGGGAACAAGGCCGGGCCAAGCCCAAC
GCCCAGGCCGTCACCCTGATCCGTCTGGTAGCGCGTTTTCCTGAAACCGTGGCTCAACTTGCCGCATTGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R2YXS2

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0N117

References