Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1793334..1793938 Replicon chromosome
Accession NZ_CP027756
Organism Pseudomonas synxantha strain R6-28-08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4K01_RS08320 Protein ID WP_124356083.1
Coordinates 1793624..1793938 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4K01_RS08315 Protein ID WP_057022035.1
Coordinates 1793334..1793621 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K01_RS08275 1788595..1789353 + 759 WP_056847351.1 MBL fold metallo-hydrolase -
C4K01_RS08280 1789381..1790094 + 714 WP_057022031.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
C4K01_RS08290 1790363..1790656 - 294 WP_057022032.1 type II toxin-antitoxin system RelE/ParE family toxin -
C4K01_RS08295 1790646..1790885 - 240 WP_014717442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
C4K01_RS08305 1791539..1791793 + 255 WP_057022033.1 hypothetical protein -
C4K01_RS08310 1791868..1793094 - 1227 WP_057022034.1 MFS transporter -
C4K01_RS08315 1793334..1793621 - 288 WP_057022035.1 helix-turn-helix domain-containing protein Antitoxin
C4K01_RS08320 1793624..1793938 - 315 WP_124356083.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4K01_RS08325 1794044..1794985 - 942 WP_057022037.1 LysR family transcriptional regulator -
C4K01_RS08330 1795143..1796459 + 1317 WP_057022038.1 MHS family MFS transporter -
C4K01_RS08335 1796471..1797703 + 1233 WP_057022039.1 Zn-dependent hydrolase -
C4K01_RS08340 1797838..1798875 + 1038 WP_057022040.1 histone deacetylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - mucA / mucD 1780183..1803154 22971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11686.46 Da        Isoelectric Point: 9.8054

>T100213 WP_124356083.1 NZ_CP027756:c1793938-1793624 [Pseudomonas synxantha]
MIFIETSVFTRRVKELIDEDAYTALQNVLVVNPSAGDVIEGTGGVRKIRVATKGHGKRGGARVIYYHFVSASQIVLLMIY
PKNEQQDLTADERKSLKAAIEHWR

Download         Length: 315 bp

>T100213 NZ_CP027756:c1793938-1793624 [Pseudomonas synxantha]
ATGATTTTCATAGAGACGTCAGTCTTCACCCGTCGCGTTAAAGAATTGATCGACGAGGATGCCTACACGGCTCTTCAGAA
CGTGTTGGTAGTCAACCCTTCTGCTGGCGATGTAATCGAGGGTACGGGTGGAGTTCGCAAGATACGAGTAGCAACCAAGG
GCCATGGCAAACGAGGCGGGGCGCGGGTGATCTATTACCACTTCGTCTCGGCATCACAGATTGTTCTACTGATGATCTAT
CCCAAAAATGAACAGCAGGACTTGACTGCCGACGAGCGCAAGTCACTGAAGGCTGCGATTGAGCACTGGAGATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10827.42 Da        Isoelectric Point: 8.8454

>AT100213 WP_057022035.1 NZ_CP027756:c1793621-1793334 [Pseudomonas synxantha]
MSRFFNELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS

Download         Length: 288 bp

>AT100213 NZ_CP027756:c1793621-1793334 [Pseudomonas synxantha]
ATGAGCAGATTTTTTAATGAACTGATGGAAAGCGTTCAAGAGATGAACGAGATCCTGCGCGGAGAACGCGAACCTTCTCG
TGAATTCCATGTTGATTCAATGCGAGTCAAAGAGATCCGCAAGGCGACAGGGCTGACCCAGGCTAAATTCGCAGCGCTGA
TTGATGTGCAACTTGGCACATTACGTAACTGGGAGCAGGGTCGTCGTGAACCTACCGGACCAGCAAAGGCATTGTTGAAA
GCTATCCATAATGACCCAGTCCATGTACTGAATGCGTTGGCTAGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References