Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 542236..542930 Replicon chromosome
Accession NZ_CP027753
Organism Pseudomonas chlororaphis strain B25

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4K04_RS02490 Protein ID WP_097134270.1
Coordinates 542236..542532 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4K04_RS02495 Protein ID WP_124318858.1
Coordinates 542529..542930 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4K04_RS02455 537860..538405 - 546 WP_124307508.1 hypothetical protein -
C4K04_RS02460 538402..538656 - 255 WP_007926835.1 acyl carrier protein -
C4K04_RS02465 538666..538926 - 261 WP_007926834.1 acyl carrier protein -
C4K04_RS02470 538901..539716 - 816 WP_124318855.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
C4K04_RS02475 539692..540423 - 732 WP_124318856.1 beta-ketoacyl synthase chain length factor -
C4K04_RS02480 540755..541525 + 771 WP_007926828.1 ParA family protein -
C4K04_RS02485 541564..541998 - 435 WP_124318857.1 thioredoxin TrxC -
C4K04_RS02490 542236..542532 + 297 WP_097134270.1 type II toxin-antitoxin system HigB family toxin Toxin
C4K04_RS02495 542529..542930 + 402 WP_124318858.1 transcriptional regulator Antitoxin
C4K04_RS02500 542934..544397 - 1464 WP_124318859.1 YdiU family protein -
C4K04_RS02505 544446..547796 - 3351 WP_124318860.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11560.36 Da        Isoelectric Point: 10.6515

>T100190 WP_097134270.1 NZ_CP027753:542236-542532 [Pseudomonas chlororaphis]
MHIITAKRIWEAKSRWPQSANALETWYRKAKSLNPADFAAIKAVFPATDKVGAFHVFDIGGNKLRIIAVVRYEVRRLYIR
HVLDHHEYDKGRWKEETR

Download         Length: 297 bp

>T100190 NZ_CP027753:542236-542532 [Pseudomonas chlororaphis]
ATGCATATCATCACCGCCAAACGAATCTGGGAGGCCAAGAGCCGCTGGCCACAATCGGCCAATGCGCTGGAAACCTGGTA
CAGAAAAGCCAAAAGCCTCAATCCGGCCGATTTTGCAGCCATCAAGGCGGTATTTCCGGCCACCGATAAAGTGGGGGCGT
TTCACGTCTTCGATATTGGCGGCAACAAGTTACGAATTATCGCCGTGGTGCGTTATGAAGTGCGACGTCTCTATATCAGG
CACGTGCTGGACCATCACGAATACGACAAGGGCAGGTGGAAGGAGGAGACCAGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14868.94 Da        Isoelectric Point: 4.5430

>AT100190 WP_124318858.1 NZ_CP027753:542529-542930 [Pseudomonas chlororaphis]
MNVLVKQAADHWHFVAPVLRKPKTEADYDALVAALDELLDLMGEDENHPVTSLVDIIGDWIEAYDEEHRPMPIASGIDVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFGVSAEVFI

Download         Length: 402 bp

>AT100190 NZ_CP027753:542529-542930 [Pseudomonas chlororaphis]
ATGAACGTTCTGGTGAAGCAGGCGGCGGATCATTGGCATTTCGTGGCGCCTGTGTTGCGTAAACCCAAGACCGAAGCCGA
TTACGATGCATTGGTCGCGGCGCTGGATGAACTGCTGGATCTCATGGGAGAGGACGAGAACCATCCAGTGACTTCGCTGG
TGGACATCATCGGCGACTGGATCGAAGCCTATGACGAAGAACACCGACCGATGCCGATAGCCAGTGGCATTGACGTCTTG
CGCTCCCTGATGCGCGAACACGGCCTGACCCAGAGCGATCTGCCAGGCGTGGGCGCGCAGTCGGTGGTTTCCGAAGTGCT
GAGCGGCAAGCGCCAGCTCAACCTGCGGCAGATCCGCTGGCTGGCCGAGCGCTTCGGTGTTTCGGCCGAGGTATTTATCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References