Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2342565..2343228 Replicon chromosome
Accession NZ_CP027734
Organism Pseudomonas sp. R1-43-08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4J87_RS10765 Protein ID WP_124366751.1
Coordinates 2342565..2342930 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4J87_RS10770 Protein ID WP_124366752.1
Coordinates 2342923..2343228 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J87_RS10740 2337648..2338202 + 555 WP_124366746.1 histidine phosphatase family protein -
C4J87_RS10745 2338248..2339003 + 756 WP_124366747.1 precorrin-6A synthase (deacetylating) -
C4J87_RS10750 2339016..2339735 + 720 WP_124366748.1 alpha/beta fold hydrolase -
C4J87_RS10755 2339849..2340403 - 555 WP_124366749.1 hypothetical protein -
C4J87_RS10760 2340476..2342284 - 1809 WP_124366750.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
C4J87_RS10765 2342565..2342930 + 366 WP_124366751.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4J87_RS10770 2342923..2343228 + 306 WP_124366752.1 XRE family transcriptional regulator Antitoxin
C4J87_RS10775 2343323..2344879 + 1557 WP_124366753.1 DUF726 domain-containing protein -
C4J87_RS10780 2344918..2346237 + 1320 WP_124366754.1 Nramp family divalent metal transporter -
C4J87_RS10785 2346239..2347171 - 933 WP_124368957.1 LysR family transcriptional regulator -
C4J87_RS10790 2347288..2347776 + 489 WP_124366755.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(17-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13797.65 Da        Isoelectric Point: 7.4719

>T100073 WP_124366751.1 NZ_CP027734:2342565-2342930 [Pseudomonas sp. R1-43-08]
MVWDIEYTDEFGEWWGDLGEKEQSSVAASVDLLGLLGPGLGFPHSSDIKGSRHGNLRELRIQHAGRPYRVLYAFDPRRCA
VLLIGGDKTAQRRWYDVHVPLAEKLYDIHLKTLRKEGRTHG

Download         Length: 366 bp

>T100073 NZ_CP027734:2342565-2342930 [Pseudomonas sp. R1-43-08]
ATGGTCTGGGACATTGAATACACGGATGAATTCGGCGAGTGGTGGGGCGACTTGGGTGAGAAGGAGCAATCTTCGGTCGC
TGCCAGCGTGGATCTGCTGGGCCTGCTCGGCCCGGGGCTTGGCTTTCCCCACAGCAGCGATATCAAGGGCTCTCGCCACG
GCAATCTGCGCGAACTGCGTATACAGCATGCAGGTCGCCCCTATCGAGTGCTGTATGCCTTTGACCCCCGGCGCTGTGCA
GTCTTGCTGATAGGTGGCGATAAAACCGCACAGCGTCGTTGGTATGACGTGCACGTACCGTTGGCAGAAAAGCTGTATGA
CATCCATTTGAAAACATTGCGCAAAGAGGGCCGTACCCATGGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11542.33 Da        Isoelectric Point: 8.0327

>AT100073 WP_124366752.1 NZ_CP027734:2342923-2343228 [Pseudomonas sp. R1-43-08]
MAKKFADLKARMTPESRADAEQLFQQHLKEMPLHELRKAQQLSQESLAKALNINQAAVSKMERRTDMYISTLRDYIRAMG
GELEIIATFPDGQVKIDNFAC

Download         Length: 306 bp

>AT100073 NZ_CP027734:2342923-2343228 [Pseudomonas sp. R1-43-08]
ATGGCTAAAAAATTCGCTGATCTTAAAGCGCGCATGACCCCCGAGTCGCGTGCCGATGCCGAGCAGCTTTTTCAACAGCA
TCTGAAAGAGATGCCCCTGCATGAGCTACGCAAGGCGCAGCAACTGAGCCAGGAAAGCCTGGCCAAGGCGCTGAATATCA
ATCAGGCGGCGGTCTCGAAAATGGAGCGTCGTACCGATATGTATATCAGCACATTGCGCGACTACATACGTGCGATGGGG
GGAGAGCTGGAAATTATCGCGACGTTTCCCGATGGCCAGGTAAAAATCGACAACTTCGCTTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References