Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2525685..2526348 Replicon chromosome
Accession NZ_CP027731
Organism Pseudomonas sp. R2-60-08W

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4J90_RS11590 Protein ID WP_124419814.1
Coordinates 2525685..2526050 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4J90_RS11595 Protein ID WP_124419815.1
Coordinates 2526043..2526348 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J90_RS11565 2520700..2521254 + 555 WP_124419810.1 histidine phosphatase family protein -
C4J90_RS11570 2521300..2522055 + 756 WP_124419811.1 precorrin-6A synthase (deacetylating) -
C4J90_RS11575 2522068..2522787 + 720 WP_124419812.1 alpha/beta fold hydrolase -
C4J90_RS11580 2522918..2523472 - 555 WP_124419813.1 hypothetical protein -
C4J90_RS11585 2523545..2525353 - 1809 WP_124362512.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
C4J90_RS11590 2525685..2526050 + 366 WP_124419814.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4J90_RS11595 2526043..2526348 + 306 WP_124419815.1 XRE family transcriptional regulator Antitoxin
C4J90_RS11600 2526443..2527999 + 1557 WP_124419816.1 DUF726 domain-containing protein -
C4J90_RS11605 2528038..2529357 + 1320 WP_124414483.1 Nramp family divalent metal transporter -
C4J90_RS11610 2529359..2530291 - 933 WP_124419817.1 LysR family transcriptional regulator -
C4J90_RS11615 2530407..2530895 + 489 WP_124419818.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(17-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.8440

>T100053 WP_124419814.1 NZ_CP027731:2525685-2526050 [Pseudomonas sp. R2-60-08W]
MVWDIEYTDEFGEWWGNLGENEQASVAASVDLLGLLGPGLGFPHSSDIRGSRHGNLRELRIQHAGRPYRVLYAFDPRRCA
VLLIGGDKTAQHRWYDVHVPVAEKLYDIHLKTLRKEGLTHG

Download         Length: 366 bp

>T100053 NZ_CP027731:2525685-2526050 [Pseudomonas sp. R2-60-08W]
ATGGTATGGGACATTGAATACACGGATGAATTCGGCGAGTGGTGGGGCAACTTGGGTGAGAATGAGCAAGCTTCGGTTGC
TGCCAGCGTGGATCTGCTGGGCCTGCTCGGCCCGGGGCTTGGTTTTCCCCACAGCAGCGATATCAGAGGCTCTCGCCACG
GTAATCTGCGCGAACTGCGTATACAGCATGCAGGTCGTCCCTATCGGGTGCTGTATGCCTTTGATCCCCGGCGCTGCGCA
GTCCTGCTGATAGGTGGCGATAAAACCGCACAGCATCGTTGGTACGACGTGCACGTACCGGTGGCGGAAAAGCTGTATGA
CATCCATTTGAAAACATTGCGCAAAGAGGGCCTTACCCATGGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11595.37 Da        Isoelectric Point: 9.6226

>AT100053 WP_124419815.1 NZ_CP027731:2526043-2526348 [Pseudomonas sp. R2-60-08W]
MAKKFADLKARMTPESRADAEQLFQQHLKEMPLHELRKAQQLSQESLAKALNINQAAVSKMERRTDMYISTLRDYIRAMG
GELEIIATFPDGQVKIDNFAR

Download         Length: 306 bp

>AT100053 NZ_CP027731:2526043-2526348 [Pseudomonas sp. R2-60-08W]
ATGGCTAAAAAATTCGCTGATCTCAAGGCGCGCATGACCCCCGAGTCGCGTGCCGATGCCGAGCAGCTTTTTCAACAGCA
TCTGAAAGAGATGCCCCTGCATGAGCTGCGCAAGGCGCAGCAACTGAGCCAGGAAAGCCTGGCCAAGGCGTTGAATATCA
ATCAGGCGGCGGTCTCGAAAATGGAGCGTCGCACCGATATGTACATCAGCACATTGCGCGACTACATACGTGCGATGGGG
GGAGAGCTGGAAATTATCGCGACGTTTCCCGATGGCCAGGTAAAAATCGACAACTTCGCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References