Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2587768..2588431 Replicon chromosome
Accession NZ_CP027730
Organism Pseudomonas sp. R3-52-08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C4J91_RS11985 Protein ID WP_124362513.1
Coordinates 2587768..2588133 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4J91_RS11990 Protein ID WP_124362514.1
Coordinates 2588126..2588431 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4J91_RS11960 2582834..2583388 + 555 WP_124362508.1 histidine phosphatase family protein -
C4J91_RS11965 2583434..2584189 + 756 WP_124362509.1 precorrin-6A synthase (deacetylating) -
C4J91_RS11970 2584202..2584921 + 720 WP_124362510.1 alpha/beta fold hydrolase -
C4J91_RS11975 2585052..2585606 - 555 WP_124362511.1 hypothetical protein -
C4J91_RS11980 2585679..2587487 - 1809 WP_124362512.1 monovalent cation:proton antiporter-2 (CPA2) family protein -
C4J91_RS11985 2587768..2588133 + 366 WP_124362513.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4J91_RS11990 2588126..2588431 + 306 WP_124362514.1 XRE family transcriptional regulator Antitoxin
C4J91_RS11995 2588526..2590082 + 1557 WP_124362515.1 DUF726 domain-containing protein -
C4J91_RS12000 2590121..2591440 + 1320 WP_124362516.1 Nramp family divalent metal transporter -
C4J91_RS12005 2591442..2592374 - 933 WP_124362517.1 LysR family transcriptional regulator -
C4J91_RS12010 2592490..2592978 + 489 WP_124362518.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13720.56 Da        Isoelectric Point: 7.1284

>T100047 WP_124362513.1 NZ_CP027730:2587768-2588133 [Pseudomonas sp. R3-52-08]
MVWDIEYTDEFGEWWGNLGEKEQSSVAASVDLLGLLGPGLGFPHSSDIKGSRHGNLRELRIQHAGRPYRVLYAFDPRRCA
VLLIGGDKTAQHRWYDVHVPVAEKLYDIHLKTLRKEGLTHG

Download         Length: 366 bp

>T100047 NZ_CP027730:2587768-2588133 [Pseudomonas sp. R3-52-08]
ATGGTATGGGACATTGAATACACGGATGAATTCGGCGAGTGGTGGGGCAACTTGGGTGAGAAGGAGCAATCTTCGGTCGC
TGCCAGCGTGGATCTGCTGGGCCTGCTCGGCCCGGGGCTTGGCTTTCCCCACAGCAGCGATATCAAGGGCTCTCGCCACG
GCAATCTGCGCGAACTGCGTATACAGCACGCAGGTCGTCCCTATCGGGTGCTGTATGCCTTTGATCCCCGGCGCTGCGCA
GTCCTGCTGATAGGTGGCGATAAAACCGCACAGCATCGTTGGTACGACGTGCACGTACCGGTGGCGGAAAAGCTGTATGA
CATCCATTTGAAAACATTGCGCAAAGAGGGCCTTACCCATGGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11623.39 Da        Isoelectric Point: 9.6547

>AT100047 WP_124362514.1 NZ_CP027730:2588126-2588431 [Pseudomonas sp. R3-52-08]
MAKKFADLKARMTPESRADAEQLFQQHLREMPLHELRKAQQLSQESLAKALNINQAAVSKMERRTDMYISTLRDYIRAMG
GELEIIATFPDGQVKIDNFAR

Download         Length: 306 bp

>AT100047 NZ_CP027730:2588126-2588431 [Pseudomonas sp. R3-52-08]
ATGGCTAAAAAATTCGCTGATCTCAAGGCGCGCATGACTCCCGAGTCGCGTGCCGATGCCGAGCAGCTTTTTCAACAGCA
TCTGAGAGAGATGCCCCTGCATGAGCTGCGCAAGGCGCAGCAACTGAGCCAGGAAAGTCTGGCCAAGGCGTTGAATATCA
ATCAGGCGGCGGTCTCGAAAATGGAGCGTCGCACCGATATGTACATCAGCACATTGCGCGACTACATACGTGCGATGGGG
GGAGAGCTGGAAATTATCGCGACGTTTCCCGATGGCCAGGTAAAAATCGACAACTTCGCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References