Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PhRel2-ATphRel2/- |
| Location | 57890..59346 | Replicon | chromosome |
| Accession | NZ_FMSN01000010 | ||
| Organism | Bacillus subtilis strain Ia1a | ||
Toxin (Protein)
| Gene name | phRel2 | Uniprot ID | - |
| Locus tag | BQ1740_RS18145 | Protein ID | WP_090558406.1 |
| Coordinates | 57890..58591 (+) | Length | 234 a.a. |
Antitoxin (Protein)
| Gene name | ATphRel2 | Uniprot ID | - |
| Locus tag | BQ1740_RS18150 | Protein ID | WP_090558408.1 |
| Coordinates | 58597..59346 (+) | Length | 250 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ1740_RS18095 (BQ1740_3709) | 53436..53822 | + | 387 | WP_090558395.1 | hypothetical protein | - |
| BQ1740_RS21780 (BQ1740_3710) | 53824..53946 | + | 123 | WP_284438230.1 | hypothetical protein | - |
| BQ1740_RS18100 (BQ1740_3711) | 53962..54132 | + | 171 | WP_090558397.1 | XkdX family protein | - |
| BQ1740_RS18105 (BQ1740_3712) | 54143..54400 | + | 258 | WP_090558398.1 | hypothetical protein | - |
| BQ1740_RS18110 (BQ1740_3713) | 54477..54755 | + | 279 | WP_015382961.1 | hemolysin XhlA family protein | - |
| BQ1740_RS18115 (BQ1740_3714) | 54771..55034 | + | 264 | WP_041345414.1 | phage holin | - |
| BQ1740_RS18120 | 55088..55909 | + | 822 | WP_090558400.1 | N-acetylmuramoyl-L-alanine amidase | - |
| BQ1740_RS18130 (BQ1740_3716) | 56159..56671 | - | 513 | WP_090558403.1 | hypothetical protein | - |
| BQ1740_RS21485 (BQ1740_3717) | 57005..57148 | + | 144 | WP_015715414.1 | hypothetical protein | - |
| BQ1740_RS18135 (BQ1740_3718) | 57179..57421 | + | 243 | WP_010329783.1 | hypothetical protein | - |
| BQ1740_RS18140 (BQ1740_3719) | 57399..57629 | + | 231 | WP_090558405.1 | DNA-binding protein | - |
| BQ1740_RS18145 (BQ1740_3720) | 57890..58591 | + | 702 | WP_090558406.1 | hypothetical protein | Toxin |
| BQ1740_RS18150 (BQ1740_3721) | 58597..59346 | + | 750 | WP_090558408.1 | DUF4065 domain-containing protein | Antitoxin |
| BQ1740_RS18155 (BQ1740_3722) | 59377..59565 | - | 189 | WP_038428499.1 | hypothetical protein | - |
| BQ1740_RS18160 | 60180..60575 | + | 396 | WP_090558409.1 | tyrosine-type recombinase/integrase | - |
| BQ1740_RS18170 | 60853..61254 | - | 402 | WP_250621501.1 | hypothetical protein | - |
| BQ1740_RS18175 | 61404..61802 | - | 399 | WP_079289008.1 | hypothetical protein | - |
| BQ1740_RS18180 (BQ1740_3724) | 61943..62279 | + | 337 | Protein_87 | tyrosine-type recombinase/integrase | - |
| BQ1740_RS18185 (BQ1740_3725) | 62577..63467 | + | 891 | WP_090558411.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL | 8494..62173 | 53679 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 234 a.a. Molecular weight: 27997.92 Da Isoelectric Point: 7.9361
>T10004 WP_090558406.1 NZ_FMSN01000010:57890-58591 [Bacillus subtilis]
MIKCTCEIESFCNDLHELILEINKLHSDFSTEFSLKKEVTHYNFKKTEIRHVTEVTDQHNLFTINNDFFILLQHYAEKLE
EIVIYSDLEYLYSDFDLRLRVKQPDSIINKLKYYRVGKPEKGKIPLKKCLNDLLGIRITIDSFDHNNECFKNTCDLLKNQ
YKITCMDSSKGDYKAFHFYFYGESNRFFPWELQIWRNSDKVTNNRSHQLHKQEYKNWASIYKNSTETIVGKKR
MIKCTCEIESFCNDLHELILEINKLHSDFSTEFSLKKEVTHYNFKKTEIRHVTEVTDQHNLFTINNDFFILLQHYAEKLE
EIVIYSDLEYLYSDFDLRLRVKQPDSIINKLKYYRVGKPEKGKIPLKKCLNDLLGIRITIDSFDHNNECFKNTCDLLKNQ
YKITCMDSSKGDYKAFHFYFYGESNRFFPWELQIWRNSDKVTNNRSHQLHKQEYKNWASIYKNSTETIVGKKR
Download Length: 702 bp
>T10004 NZ_FMSN01000010:57890-58591 [Bacillus subtilis]
TTGATTAAATGCACTTGTGAAATCGAGTCATTTTGCAACGATCTTCATGAGTTGATACTAGAAATTAATAAGTTGCATAG
TGATTTTTCAACCGAATTCAGCTTGAAAAAAGAAGTGACACATTATAATTTTAAAAAAACTGAAATAAGACATGTTACAG
AGGTTACTGACCAACATAACCTCTTCACAATTAACAATGACTTTTTTATTTTACTCCAACATTACGCTGAAAAACTGGAG
GAAATTGTTATTTACAGCGATTTGGAATATCTATATAGCGATTTTGACTTGCGCCTTAGAGTAAAGCAACCAGATAGCAT
CATCAATAAGCTTAAATATTATCGTGTTGGGAAACCGGAAAAAGGGAAAATACCCTTAAAGAAATGCTTAAACGACTTGC
TGGGGATAAGAATAACAATTGATTCCTTTGACCATAATAATGAATGTTTTAAAAATACCTGTGATCTCTTGAAGAATCAA
TACAAAATAACTTGTATGGATTCTTCAAAAGGTGATTATAAAGCATTCCATTTTTATTTTTATGGAGAGAGCAACAGATT
TTTTCCTTGGGAACTTCAGATTTGGAGAAATTCAGATAAAGTAACAAATAATCGATCTCACCAACTGCATAAGCAAGAAT
ATAAAAATTGGGCATCGATTTATAAAAACTCTACAGAAACAATTGTGGGGAAAAAGAGGTGA
TTGATTAAATGCACTTGTGAAATCGAGTCATTTTGCAACGATCTTCATGAGTTGATACTAGAAATTAATAAGTTGCATAG
TGATTTTTCAACCGAATTCAGCTTGAAAAAAGAAGTGACACATTATAATTTTAAAAAAACTGAAATAAGACATGTTACAG
AGGTTACTGACCAACATAACCTCTTCACAATTAACAATGACTTTTTTATTTTACTCCAACATTACGCTGAAAAACTGGAG
GAAATTGTTATTTACAGCGATTTGGAATATCTATATAGCGATTTTGACTTGCGCCTTAGAGTAAAGCAACCAGATAGCAT
CATCAATAAGCTTAAATATTATCGTGTTGGGAAACCGGAAAAAGGGAAAATACCCTTAAAGAAATGCTTAAACGACTTGC
TGGGGATAAGAATAACAATTGATTCCTTTGACCATAATAATGAATGTTTTAAAAATACCTGTGATCTCTTGAAGAATCAA
TACAAAATAACTTGTATGGATTCTTCAAAAGGTGATTATAAAGCATTCCATTTTTATTTTTATGGAGAGAGCAACAGATT
TTTTCCTTGGGAACTTCAGATTTGGAGAAATTCAGATAAAGTAACAAATAATCGATCTCACCAACTGCATAAGCAAGAAT
ATAAAAATTGGGCATCGATTTATAAAAACTCTACAGAAACAATTGTGGGGAAAAAGAGGTGA
Antitoxin
Download Length: 250 a.a. Molecular weight: 28735.86 Da Isoelectric Point: 6.4984
>AT10004 WP_090558408.1 NZ_FMSN01000010:58597-59346 [Bacillus subtilis]
MAFHFIAIISDFSGGRRIGWHYSSEERLDKNYILEFFERVKEKCGMVQFGIHKLSTDSTSWQSVTEKDSFFDDVYVTEDI
STFIDVISKDKELTAYDVAKFVLSFKPASHLKLQKLLYYIYAEFLLKTGEKLFKEPIVAFKYGPVIEDIFYRYKVHGKSE
IDYEEDATIKLRTDDLVITPSFMKILSSEHGIEALKCISDVLAKYGKYSASGLVDKTHQAGGPWKRVYKPGQNCVITDEL
ITQYHQYAT
MAFHFIAIISDFSGGRRIGWHYSSEERLDKNYILEFFERVKEKCGMVQFGIHKLSTDSTSWQSVTEKDSFFDDVYVTEDI
STFIDVISKDKELTAYDVAKFVLSFKPASHLKLQKLLYYIYAEFLLKTGEKLFKEPIVAFKYGPVIEDIFYRYKVHGKSE
IDYEEDATIKLRTDDLVITPSFMKILSSEHGIEALKCISDVLAKYGKYSASGLVDKTHQAGGPWKRVYKPGQNCVITDEL
ITQYHQYAT
Download Length: 750 bp
>AT10004 NZ_FMSN01000010:58597-59346 [Bacillus subtilis]
ATGGCATTTCATTTTATCGCGATCATTAGTGATTTTTCTGGTGGTAGAAGAATTGGCTGGCATTATTCAAGTGAGGAAAG
ATTGGATAAAAATTACATTTTGGAATTCTTTGAGAGAGTTAAGGAAAAGTGCGGTATGGTCCAATTTGGAATTCACAAAT
TATCAACGGATTCAACCAGCTGGCAATCTGTAACTGAGAAAGATTCCTTTTTCGATGATGTATATGTTACAGAAGATATT
TCAACCTTTATAGATGTGATTTCTAAAGACAAAGAATTAACCGCATATGACGTAGCAAAATTTGTCTTATCATTTAAACC
GGCGTCTCACTTAAAATTGCAAAAACTACTTTATTATATCTACGCAGAATTTTTGTTGAAAACAGGGGAAAAGTTATTCA
AGGAACCTATAGTAGCGTTTAAATATGGTCCAGTTATCGAGGATATTTTCTATAGATATAAAGTTCACGGGAAATCTGAA
ATAGATTATGAAGAAGATGCTACCATCAAGCTCCGTACTGATGATTTAGTAATAACACCGTCTTTTATGAAGATTTTATC
TTCTGAGCATGGTATAGAGGCTCTTAAATGTATTAGCGATGTACTTGCTAAGTATGGAAAATATTCTGCATCTGGTTTAG
TTGATAAAACTCATCAAGCTGGTGGACCTTGGAAAAGAGTATACAAGCCAGGTCAAAATTGTGTAATAACAGATGAACTT
ATTACTCAGTATCACCAATATGCTACGTAA
ATGGCATTTCATTTTATCGCGATCATTAGTGATTTTTCTGGTGGTAGAAGAATTGGCTGGCATTATTCAAGTGAGGAAAG
ATTGGATAAAAATTACATTTTGGAATTCTTTGAGAGAGTTAAGGAAAAGTGCGGTATGGTCCAATTTGGAATTCACAAAT
TATCAACGGATTCAACCAGCTGGCAATCTGTAACTGAGAAAGATTCCTTTTTCGATGATGTATATGTTACAGAAGATATT
TCAACCTTTATAGATGTGATTTCTAAAGACAAAGAATTAACCGCATATGACGTAGCAAAATTTGTCTTATCATTTAAACC
GGCGTCTCACTTAAAATTGCAAAAACTACTTTATTATATCTACGCAGAATTTTTGTTGAAAACAGGGGAAAAGTTATTCA
AGGAACCTATAGTAGCGTTTAAATATGGTCCAGTTATCGAGGATATTTTCTATAGATATAAAGTTCACGGGAAATCTGAA
ATAGATTATGAAGAAGATGCTACCATCAAGCTCCGTACTGATGATTTAGTAATAACACCGTCTTTTATGAAGATTTTATC
TTCTGAGCATGGTATAGAGGCTCTTAAATGTATTAGCGATGTACTTGCTAAGTATGGAAAATATTCTGCATCTGGTTTAG
TTGATAAAACTCATCAAGCTGGTGGACCTTGGAAAAGAGTATACAAGCCAGGTCAAAATTGTGTAATAACAGATGAACTT
ATTACTCAGTATCACCAATATGCTACGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| AT10008 | Helicobacter sp. 13S00482-2 NODE_7_length_88364_cov_126.498_ID_13 |
30 |
100 |
0.329 |
Multiple sequence alignment
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|
References
(1) Tatsuaki Kurata et al. (2021) RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis. Molecular Cell 81(15):3160-3170.e9. [PubMed:34174184]
(2) Tatsuaki Kurata et al. (2022) A hyperpromiscuous antitoxin protein domain for the neutralization of diverse toxin domains. Proceedings of The National Academy of Sciences of The United States of America 119(6):e2102212119. [PubMed:35121656]
(3) Steffi Jimmy et al. (2020) A widespread toxin-antitoxin system exploiting growth control via alarmone signaling. Proceedings of The National Academy of Sciences of The United States of America 117(19):10500-10510. [PubMed:32345719]